Human Body-on-Chip platform enables in vitro prediction of drug behaviors in humans

3 insightful articles on the possibility to miniaturize organism testing through miniaturized models:

Overview at the Wyss Institute

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  • A. Herland, B.M. Maoz, D. Das, M.R. Somayaji, R. Prantil-Baun, R. Novak, M. Cronce, T. Huffstater, S.S.F. Jeanty, M. Ingram, A. Chalkiadaki, D. Benson Chou, S. Marquez, A. Delahanty, S. Jalili-Firoozinezhad, Y. Milton, A. Sontheimer-Phelps, B. Swenor, O. Levy, K.K. Parker, A. Przekwas, and D.E. Ingber, "Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips", Nature Biomedical Engineering, vol. 4, pp. 421-436, 2020.
  • R. Novak, M. Ingram, S. Marquez, D. Das, A. Delahanty, A. Herland, B.M. Maoz, S.S.F. Jeanty, M.R. Somayaji, M. Burt, E. Calamari, A. Chalkiadaki, A. Cho, Y. Choe, D.B. Chou, M. Cronce, S. Dauth, T. Divic, J. Fernandez-Alcon, T. Ferrante, J. Ferrier, E.A. FitzGerald, R. Fleming, S. Jalili-Firoozinezhad, T. Grevesse, J.A. Goss, T. Hamkins-Indik, O. Henry, C. Hinojosa, T. Huffstater, K. Jang, V. Kujala, L. Leng, R. Mannix, Y. Milton, J. Nawroth, B.A. Nestor, C.F. Ng, B. O’Connor, T. Park, H. Sanchez, J. Sliz, A. Sontheimer-Phelps, B. Swenor, G. Thompson, G.J. Touloumes, Z. Tranchemontagne, N. Wen, M. Yadid, A. Bahinski, G.A. Hamilton, D. Levner, O. Levy, A. Przekwas, R. Prantil-Baun, K.K. Parker, and D.E. Ingber, "Robotic fluidic coupling and interrogation of multiple vascularized organ chips", Nature Biomedical Engineering, vol. 4, pp. 407-420, 2020.