medchem

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Michael J. Soth, Kang Le, Maria Emilia Di Francesco, Matthew M. Hamilton, Gang Liu, Jason P. Burke, Chris L. Carroll, Jeffrey J. Kovacs, Jennifer P. Bardenhagen, Christopher A. Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R. Garvey, Jason P. Gay, Mary K. Geck Do, Jennifer Greer, Michelle Han, Angela Harris, Zachary Herrera, Sha Huang, Virginia Giuliani, Yongying Jiang, Sarah B. Johnson, Troy A. Johnson, Zhijun Kang, Paul G. Leonard, Zhen Liu, Timothy McAfoos, Meredith Miller, Pietro Morlacchi, Robert A. Mullinax, Wylie S. Palmer, Jihai Pang, Norma Rogers, Charles M. Rudin, Hannah E. Shepard, Nakia D. Spencer, Jay Theroff, Qi Wu, Alan Xu, Ju Anne Yau, Giulio Draetta, Carlo Toniatti, Timothy P. Heffernan, and Philip Jones
feedproxy.google.com/~r/acs/jmcmar/~3/tx0UPHOUdnI/acs.jmedchem.0c01398

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Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Bo Li, Yongliang Li, Céline Tomkiewicz-Raulet, Pascal Dao, Daniel Lietha, Expédite Yen-Pon, Zhiyun Du, Xavier Coumoul, Christiane Garbay, Mélanie Etheve-Quelquejeu, and Huixiong Chen
feedproxy.google.com/~r/acs/jmcmar/~3/zrv2Rqxnw2M/acs.jmedchem.0c01059

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Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5′-Nucleotidase Inhibitors

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Abida Ashraf, Zahid Shafiq, Muhammad Siraj Khan Jadoon, Muhammad Nawaz Tahir, Julie Pelletier, Jean Sevigny, Muhammad Yaqub, and Jamshed Iqbal
feedproxy.google.com/~r/acs/amclct/~3/b9od-P2GdSc/acsmedchemlett.0c00343

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Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: James S. Scott, Thomas A. Moss, Bernard Barlaam, Paul R. J. Davey, Gary Fairley, Eric T. Gangl, Ryan D. R. Greenwood, Holia Hatoum-Mokdad, Andrew S. Lister, David Longmire, Radoslaw Polanski, Stephen Stokes, Michael J. Tucker, Jeffrey G. Varnes, and Bin Yang
feedproxy.google.com/~r/acs/amclct/~3/UoxnN4llQJw/acsmedchemlett.0c00505

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Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Alexander Hillisch, Kersten M. Gericke, Swen Allerheiligen, Susanne Roehrig, Martina Schaefer, Adrian Tersteegen, Simone Schulz, Philip Lienau, Mark Gnoth, Vera Puetter, Roman C. Hillig, and Stefan Heitmeier
feedproxy.google.com/~r/acs/jmcmar/~3/L-7QND9DtgQ/acs.jmedchem.0c01035

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α-Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Michele Rossi, Sabrina Petralla, Michele Protti, Monica Baiula, Tereza Kobrlova, Ondrej Soukup, Santi Mario Spampinato, Laura Mercolini, Barbara Monti, and Maria Laura Bolognesi
feedproxy.google.com/~r/acs/amclct/~3/sw6LH8qOc8Q/acsmedchemlett.0c00375

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Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Richard J. D. Hatley, Panayiotis A. Procopiou, Steven P. McLachlan, Laura E. Westendorf, Nicholas A. Meanwell, William R. Ewing, and Simon J. F. Macdonald
feedproxy.google.com/~r/acs/jmcmar/~3/gBpbaCilRGI/acs.jmedchem.0c01159

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Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Mohammad M. Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A. Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S. Anderson, and William L. Jorgensen
feedproxy.google.com/~r/acs/amclct/~3/h1HtFAH38eo/acsmedchemlett.0c00521

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Identification, Structure–Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Jinhui Wang, Weiyang Jin, Xiaoxin Zhou, Jiaqi Li, Chengdong Xu, Zhongjun Ma, Jianan Wang, Lele Qin, Biao Zhou, Wanjing Ding, Tingting Gao, Hangping Yao, and Zhe Chen
feedproxy.google.com/~r/acs/jmcmar/~3/iWemGZswDDQ/acs.jmedchem.0c01271

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Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial In Vitro and In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Nidja Rehberg, Gereon A. Sommer, Daniel Drießen, Marco Kruppa, Emmanuel T. Adeniyi, Shang Chen, Lin Wang, Karina Wolf, Boris O. A. Tasch, Thomas R. Ioerger, Kui Zhu, Thomas J. J. Müller, and Rainer Kalscheuer
feedproxy.google.com/~r/acs/jmcmar/~3/LyWxnXm5h58/acs.jmedchem.0c00826

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Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C. de Sousa^, John Okombo^, Keletso Maepa^, Timothy J. Egan^Δ, Lyn-Marie Birkholtz, Gregory S. Basarab, Sergio Wittlin, Paul V. Fish, Leslie J. Street, James Duffy+, and Kelly ChibaleΔ
feedproxy.google.com/~r/acs/jmcmar/~3/Te9JL74Z76Y/acs.jmedchem.0c01411

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Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Giuseppe Felice Mangiatordi, Francesca Intranuovo, Pietro Delre, Francesca Serena Abatematteo, Carmen Abate, Mauro Niso, Teresa Maria Creanza, Nicola Ancona, Angela Stefanachi, and Marialessandra Contino
feedproxy.google.com/~r/acs/jmcmar/~3/HFu_3FSjaGU/acs.jmedchem.0c01357

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Structure–Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Wenhu Zhan, Pradeep K. Singh, Yi Ban, Xiaoping Qing, Marie Dominique Ah Kioon, Hao Fan, Quanju Zhao, Rong Wang, George Sukenick, Jane Salmon, J. David Warren, Xiaojing Ma, Franck J. Barrat, Carl F. Nathan, and Gang Lin
feedproxy.google.com/~r/acs/jmcmar/~3/HW2oIxt9R_0/acs.jmedchem.0c01520

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Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Marvin Korff, Lukas Imberg, Jonas M. Will, Nico Bückreiß, Svetlana A. Kalinina, Benjamin M. Wenzel, Gregor A. Kastner, Constantin G. Daniliuc, Maximilian Barth, Ruzanna A. Ovsepyan, Kirill R. Butov, Hans-Ulrich Humpf, Matthias Lehr, Mikhail A. Panteleev, Antti Poso, Uwe Karst, Torsten Steinmetzer, Gerd Bendas, and Dmitrii V. Kalinin
feedproxy.google.com/~r/acs/jmcmar/~3/IM8kQzLrqQM/acs.jmedchem.0c01635

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One-Step, Rapid, 18F–19F Isotopic Exchange Radiolabeling of Difluoro-dioxaborinins: Substituent Effect on Stability and In Vivo Applications

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Feifei An, Fuad Nurili, Haluk Sayman, Zahide Ozer, Huseyin Cakiroglu, Omer Aras, and Richard Ting
feedproxy.google.com/~r/acs/jmcmar/~3/HdZWfUGX9jc/acs.jmedchem.0c00997

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Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Jonathan T. Lloyd, Kyle McLaughlin, Mulu Y. Lubula, Jamie C. Gay, Andrea Dest, Cong Gao, Margaret Phillips, Marco Tonelli, Gabriel Cornilescu, Matthew R. Marunde, Chiara M. Evans, Samuel P. Boyson, Samuel Carlson, Michael-Christopher Keogh, John L. Markley, Seth Frietze, and Karen C. Glass
feedproxy.google.com/~r/acs/jmcmar/~3/kRwdYl44qgo/acs.jmedchem.0c01178

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Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Alicia Peschel, Fernanda C. Cardoso, Andrew A. Walker, Thomas Durek, M. Rhia L. Stone, Nayara Braga Emidio, Philip E. Dawson, Markus Muttenthaler, and Glenn F. King
feedproxy.google.com/~r/acs/jmcmar/~3/S0CSiXEvYGE/acs.jmedchem.0c01107

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