chemical_biology

RASS‐Enabled S/P–C and S–N Bond Formation for DEL Synthesis

Flood, Baran, Dawson et al.

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  • D.T. Flood, X. Zhang, X. Fu, Z. Zhao, S. Asai, B.B. Sanchez, E.J. Sturgell, J.C. Vantourout, P. Richardson, M.E. Flanagan, D.W. Piotrowski, D.K. Kölmel, J. Wan, M. Tsai, J.S. Chen, P.S. Baran, and P.E. Dawson, "RASS‐Enabled S/P−C and S−N Bond Formation for DEL Synthesis", Angewandte Chemie, vol. 132, pp. 7447-7453, 2020. http://dx.doi.org/10.1002/ange.201915493
  • Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors

    Astra-Zeneca

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  • R.T. Howard, P. Hemsley, P. Petteruti, C.N. Saunders, J.A. Molina Bermejo, J.S. Scott, J.W. Johannes, and E.W. Tate, "Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors", ACS Chemical Biology, vol. 15, pp. 325-333, 2020. http://dx.doi.org/10.1021/acschembio.9b00963
  • Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study

    Genentech – Pharmaron
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  • S. Yamazoe, J. Tom, Y. Fu, W. Wu, L. Zeng, C. Sun, Q. Liu, J. Lin, K. Lin, W.J. Fairbrother, and S.T. Staben, "Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study", Journal of Medicinal Chemistry, vol. 63, pp. 2807-2813, 2019. http://dx.doi.org/10.1021/acs.jmedchem.9b01167
  • Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a ß-Lactone Antibiotic

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  • T.A. Scott, S.F.D. Batey, P. Wiencek, G. Chandra, S. Alt, C.S. Francklyn, and B. Wilkinson, "Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic", ACS Chemical Biology, vol. 14, pp. 2663-2671, 2019. http://dx.doi.org/10.1021/acschembio.9b00590
  • Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

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  • T.S. Lou, S.W. Bagley, and M.C. Willis, "Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents", Angewandte Chemie International Edition, vol. 58, pp. 18859-18863, 2019. http://dx.doi.org/10.1002/anie.201910871
  • Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway

    [1]

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  • P. Ottis, C. Palladino, P. Thienger, A. Britschgi, C. Heichinger, M. Berrera, A. Julien-Laferriere, F. Roudnicky, T. Kam-Thong, J.R. Bischoff, B. Martoglio, and P. Pettazzoni, "Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway", ACS Chemical Biology, 2019. http://dx.doi.org/10.1021/acschembio.9b00525