Life_Sciences

Structure–Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Juan Zhou†∥, Elliot D. Mock†∥, Karol Al Ayed†, Xinyu Di‡, Vasudev Kantae‡, Lindsey Burggraaff§, Anna F. Stevens†, Andrea Martella†, Florian Mohr†, Ming Jiang†, Tom van der Wel†, Tiemen J. Wendel†, Tim P. Ofman†, Yvonne Tran†, Nicky de Koster†, Gerard J.P. van Westen§, Thomas Hankemeier‡, and Mario van der Stelt*†
feedproxy.google.com/~r/acs/jmcmar/~3/7SShcpk9uao/acs.jmedchem.0c00522

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Bivalent Inhibitors of Prostate-Specific Membrane Antigen Conjugated to Desferrioxamine B Squaramide Labeled with Zirconium-89 or Gallium-68 for Diagnostic Imaging of Prostate Cancer

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Asif Noor†, Jessica K. Van Zuylekom‡, Stacey E. Rudd†, Kelly Waldeck‡, Peter D. Roselt‡, Mohammad B. Haskali‡, Michael P. Wheatcroft§, Eddie Yan§, Rodney J. Hicks‡∥, Carleen Cullinane‡∥, and Paul S. Donnelly*†
feedproxy.google.com/~r/acs/jmcmar/~3/Ybmh4i__hZU/acs.jmedchem.0c00291

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Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Michael G. Thomas*†, Manu De Rycker†, Richard J. Wall†, Daniel Spinks†, Ola Epemolu†, Sujatha Manthri†, Suzanne Norval†, Maria Osuna-Cabello†, Stephen Patterson†, Jennifer Riley†, Frederick R. C. Simeons†, Laste Stojanovski†, John Thomas†, Stephen Thompson†, Claire Naylor†, Jose M. Fiandor‡, Paul G. Wyatt†, Maria Marco‡, Susan Wyllie†, Kevin D. Read†, Timothy J. Miles*‡, and Ian H. Gilbert*†
feedproxy.google.com/~r/acs/jmcmar/~3/717LENuQUPQ/acs.jmedchem.0c00705

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Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Caroline B. F. Mourão†‡, Guilherme D. Brand§, João Paulo C. Fernandes∥, Maura V. Prates⊥, Carlos Bloch, Jr⊥, João Alexandre R. G. Barbosa∥, Sônia M. Freitas∥, Rita Restano-Cassulini#, Lourival D. Possani#, and Elisabeth F. Schwartz*†
feedproxy.google.com/~r/acs/jmcmar/~3/9AZoxmlWYL0/acs.jmedchem.0c00686

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Cyanobacterial Dihydroxyacid Dehydratases Are a Promising Growth Inhibition Target

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ACS Chemical Biology

ACS Chemical Biology: Latest Articles (ACS Publications)
Authors: Peilan Zhang†∥, Brian S. MacTavish‡∥, Guang Yang†, Manyun Chen†, Jaehyeok Roh†, Kevin R. Newsome‡, Steven D. Bruner*‡, and Yousong Ding*†
feedproxy.google.com/~r/acs/acbcct/~3/3pcDaWFS7GM/acschembio.0c00507

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Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Christopher P. Mussari†, Dharmpal S. Dodd†, Ratna Kumar Sreekantha‡, Laxman Pasunoori‡, Honghe Wan†, Shana L. Posy†, David Critton†, Stefan Ruepp†, Murali Subramanian‡, Andrew Watson†, Paul Davies†, Gary L. Schieven†, Luisa M. Salter-Cid†, Ratika Srivastava‡, Debarati Mazumder Tagore‡, Shailesh Dudhgaonkar‡, Michael A. Poss†, Percy H. Carter†, and Alaric J. Dyckman*†
feedproxy.google.com/~r/acs/amclct/~3/kucKpl6KUwQ/acsmedchemlett.0c00264

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Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Amit Mahindra†⊥, Omar Janha‡⊥, Kopano Mapesa†, Ana Sanchez-Azqueta‡, Mahmood M. Alam§, Alfred Amambua-Ngwa∥, Davis C. Nwakanma∥, Andrew B. Tobin*‡, and Andrew G. Jamieson*†
feedproxy.google.com/~r/acs/jmcmar/~3/u-f-cjscb00/acs.jmedchem.0c00451

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Fucosylated Chondroitin Sulfate 9–18 Oligomers Exhibit Molecular Size-Independent Antithrombotic Activity while Circulating in the Blood

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ACS Chemical Biology

ACS Chemical Biology: Latest Articles (ACS Publications)
Authors: Lufeng Yan†‡, Danli Wang†, Yanlei Yu‡, Fuming Zhang‡, Xingqian Ye†, Robert J. Linhardt*‡, and Shiguo Chen*†
feedproxy.google.com/~r/acs/acbcct/~3/M7m4mK2Aow0/acschembio.0c00439

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Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: F. Javier Pérez-Areales†, María Garrido‡, Ester Aso§, Manuela Bartolini∥, Angela De Simone⊥, Alba Espargaró#, Tiziana Ginex∇, Raimon Sabate#, Belén Pérez○, Vincenza Andrisano◆, Dolors Puigoriol-Illamola¶, Mercè Pallàs¶, F. Javier Luque∇, María Isabel Loza⋈, José Brea⋈, Isidro Ferrer§⧓, Francisco Ciruela§, Angel Messeguer‡, and Diego Muñoz-Torrero*†
feedproxy.google.com/~r/acs/jmcmar/~3/VhSzHdAWDzA/acs.jmedchem.0c00528

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Dual Cherenkov Radiation-Induced Near-Infrared Luminescence Imaging and Photodynamic Therapy toward Tumor Resection

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Vivian Lioret†, Pierre-Simon Bellaye‡, Christine Arnould§, Bertrand Collin‡, and Richard A. Decréau*†
feedproxy.google.com/~r/acs/jmcmar/~3/zqoK4fJ3FKw/acs.jmedchem.0c00625

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A Phosphoramidate Strategy Enables Membrane Permeability of a Non-nucleotide Inhibitor of the Prolyl Isomerase Pin1

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Daniel M. C. Schwarz†, Sarah K. Williams†, Maxwell Dillenburg‡, Carston R. Wagner‡, and Jason E. Gestwicki*†
feedproxy.google.com/~r/acs/amclct/~3/XASUtFOevwo/acsmedchemlett.0c00170

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Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Chen-Xi Wang, Zi-Lin Zhang, Qi-Kun Yin, Jia-Li Tu, Jia-En Wang, Yao-Hao Xu, Yong Rao, Tian-Miao Ou, Shi-Liang Huang, Ding Li, Hong-Gen Wang, Qing-Jiang Li, Jia-Heng Tan, Shuo-Bin Chen*, and Zhi-Shu Huang*
feedproxy.google.com/~r/acs/jmcmar/~3/Mvi2eLPHmsc/acs.jmedchem.0c00917

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Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Rachel L. Palte*†, Sebastian E. Schneider*†, Michael D. Altman†, Robert P. Hayes§, Shuhei Kawamura‡, Brian M. Lacey∥, My Sam Mansueto∥, Michael Reutershan‡, Phieng Siliphaivanh‡, Christopher Sondey∥, Haiyan Xu∥, Zangwei Xu∥, Yingchun Ye‡, and Michelle R. Machacek‡
feedproxy.google.com/~r/acs/amclct/~3/tKl1sr-VywY/acsmedchemlett.9b00525

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Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: David R. Witty*†, Giuseppe Alvaro†§, Dominique Derjean†, Gerard M. P. Giblin†, Kevin Gunn†, Charles Large†§, David T. Macpherson†, Valerie Morisset†, Davina Owen†, Joanne Palmer†, Francois Rugiero†, Simon Tate†, Christopher A. Hinckley‡, and Himanshu Naik‡
feedproxy.google.com/~r/acs/amclct/~3/w601NcDuZnI/acsmedchemlett.0c00263

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Structure–Activity Relationships of Daptomycin Lipopeptides

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: John A. Karas†, Glen P. Carter‡, Benjamin P. Howden‡, Adrianna M. Turner‡, Olivia K. A. Paulin†, James D. Swarbrick†, Mark. A. Baker§, Jian Li*?, and Tony Velkov*†
feedproxy.google.com/~r/acs/jmcmar/~3/lA1wp5bKV_o/acs.jmedchem.0c00780

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Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Bin Ma*, Tonika Bohnert, Kevin L. Otipoby†, Eric Tien, Million Arefayene, Judy Bai, Bekim Bajrami, Eris Bame, Timothy R. Chan‡, Michael Humora§, J. Michael MacPhee?, Douglas Marcotte?, Devangi Mehta#, Claire M. Metrick, George Moniz, Evelyne Polack, Urjana Poreci, Annick Prefontaine, Sarah Sheikh8, Patricia Schroeder?, Karen Smirnakis, Lei Zhang, Fengmei Zheng, and Brian T. Hopkins*
feedproxy.google.com/~r/acs/jmcmar/~3/eJpP2sx64tE/acs.jmedchem.0c00702

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Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Hongyi Zhao†, Bin Wang§, Lei Fu§, Gang Li†, Haijia Lu†, Yuke Liu‡, Li Sheng‡, Yan Li‡, Baoxi Zhang?, Yang Lu?, Chen Ma?, Haihong Huang*†, Dongfeng Zhang*†, and Yu Lu*§
feedproxy.google.com/~r/acs/jmcmar/~3/OVxT0AWLZ5M/acs.jmedchem.0c00500

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