Life_Sciences

Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Giuseppe Felice Mangiatordi, Francesca Intranuovo, Pietro Delre, Francesca Serena Abatematteo, Carmen Abate, Mauro Niso, Teresa Maria Creanza, Nicola Ancona, Angela Stefanachi, and Marialessandra Contino
feedproxy.google.com/~r/acs/jmcmar/~3/HFu_3FSjaGU/acs.jmedchem.0c01357

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Structure–Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Wenhu Zhan, Pradeep K. Singh, Yi Ban, Xiaoping Qing, Marie Dominique Ah Kioon, Hao Fan, Quanju Zhao, Rong Wang, George Sukenick, Jane Salmon, J. David Warren, Xiaojing Ma, Franck J. Barrat, Carl F. Nathan, and Gang Lin
feedproxy.google.com/~r/acs/jmcmar/~3/HW2oIxt9R_0/acs.jmedchem.0c01520

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Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

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ACS Chemical Biology

ACS Chemical Biology: Latest Articles (ACS Publications)
Authors: Marie Flamme, Pascal Röthlisberger, Fabienne Levi-Acobas, Mohit Chawla, Romina Oliva, Luigi Cavallo, Gilles Gasser, Philippe Marlière, Piet Herdewijn, and Marcel Hollenstein
feedproxy.google.com/~r/acs/acbcct/~3/CZ328yJbIjg/acschembio.0c00396

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Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Marvin Korff, Lukas Imberg, Jonas M. Will, Nico Bückreiß, Svetlana A. Kalinina, Benjamin M. Wenzel, Gregor A. Kastner, Constantin G. Daniliuc, Maximilian Barth, Ruzanna A. Ovsepyan, Kirill R. Butov, Hans-Ulrich Humpf, Matthias Lehr, Mikhail A. Panteleev, Antti Poso, Uwe Karst, Torsten Steinmetzer, Gerd Bendas, and Dmitrii V. Kalinin
feedproxy.google.com/~r/acs/jmcmar/~3/IM8kQzLrqQM/acs.jmedchem.0c01635

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One-Step, Rapid, 18F–19F Isotopic Exchange Radiolabeling of Difluoro-dioxaborinins: Substituent Effect on Stability and In Vivo Applications

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Feifei An, Fuad Nurili, Haluk Sayman, Zahide Ozer, Huseyin Cakiroglu, Omer Aras, and Richard Ting
feedproxy.google.com/~r/acs/jmcmar/~3/HdZWfUGX9jc/acs.jmedchem.0c00997

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Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Jonathan T. Lloyd, Kyle McLaughlin, Mulu Y. Lubula, Jamie C. Gay, Andrea Dest, Cong Gao, Margaret Phillips, Marco Tonelli, Gabriel Cornilescu, Matthew R. Marunde, Chiara M. Evans, Samuel P. Boyson, Samuel Carlson, Michael-Christopher Keogh, John L. Markley, Seth Frietze, and Karen C. Glass
feedproxy.google.com/~r/acs/jmcmar/~3/kRwdYl44qgo/acs.jmedchem.0c01178

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Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Robert Koralewski, Barbara Dymek, Marzena Mazur, Piotr Sklepkiewicz, Sylwia Olejniczak, Wojciech Czestkowski, Krzysztof Matyszewski, Gleb Andryianau, Piotr Niedziejko, Michal Kowalski, Mariusz Gruza, Bartomiej Borek, Karol Jedrzejczak, Agnieszka Bartoszewicz, Elżbieta Pluta, Aleksandra Rymaszewska, Magdalena Kania, Tomasz Rejczak, Sylwia Piasecka, Michal Mlacki, Marcin Mazurkiewicz, Micha Piotrowicz, Magdalena Salamon, Agnieszka Zagozdzon, Agnieszka Napiorkowska-Gromadzka, Aneta Bartlomiejczak, Witold Mozga, Pawe Dobrzański, Karolina Dzwonek, Jakub Golab, Marcin Nowotny, Jacek Olczak, and Adam Golebiowski
feedproxy.google.com/~r/acs/jmcmar/~3/vwN1SRwwM7Q/acs.jmedchem.0c01179

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Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Alicia Peschel, Fernanda C. Cardoso, Andrew A. Walker, Thomas Durek, M. Rhia L. Stone, Nayara Braga Emidio, Philip E. Dawson, Markus Muttenthaler, and Glenn F. King
feedproxy.google.com/~r/acs/jmcmar/~3/S0CSiXEvYGE/acs.jmedchem.0c01107

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Novel Copper-Containing Cytotoxic Agents Based on 2-Thioxoimidazolones

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Olga O. Krasnovskaya&, Dmitry A. Guk&, Alexey E. Naumov, Vita N. Nikitina, Alevtina S. Semkina, Kseniya Yu. Vlasova, Vadim Pokrovsky, Oksana O. Ryabaya, Saida S. Karshieva, Dmitry A. Skvortsov, Irina V. Zhirkina, Radik R. Shafikov, Petr V. Gorelkin, Alexander N. Vaneev, Alexander S. Erofeev, Dmitrii M. Mazur, Viktor A. Tafeenko, Vladimir I. Pergushov, Mikhail Ya. Melnikov, Mikhail A. Soldatov, Victor V. Shapovalov, Alexander V. Soldatov, Roman. A. Akasov, Vasily M. Gerasimov, Dmitry A. Sakharov, Anna A. Moiseeva, Nikolay V. Zyk, Elena K. Beloglazkina, and Alexander G. Majouga
feedproxy.google.com/~r/acs/jmcmar/~3/NszjcEeuq0I/acs.jmedchem.0c01196

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Facile Synthesis and Metabolic Incorporation of m-DAP Bioisosteres Into Cell Walls of Live Bacteria

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ACS Chemical Biology

ACS Chemical Biology: Latest Articles (ACS Publications)
Authors: Alexis J. Apostolos, Julia M. Nelson, José Rogério A. Silva, Jerônimo Lameira, Alecia M. Achimovich, Andreas Gahlmann, Cláudio N. Alves, and Marcos M. Pires
feedproxy.google.com/~r/acs/acbcct/~3/l3rajqlvt_Q/acschembio.0c00618

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A Peptidyl Inhibitor that Blocks Calcineurin–NFAT Interaction and Prevents Acute Lung Injury

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Patrick G. Dougherty, Manjula Karpurapu, Amritendu Koley, Jessica K. Lukowski, Ziqing Qian, Teja Srinivas Nirujogi, Luiza Rusu, Sangwoon Chung, Amanda B. Hummon, Hao W. Li, John W. Christman, and Dehua Pei
feedproxy.google.com/~r/acs/jmcmar/~3/-Ga6iZF-Lng/acs.jmedchem.0c01236

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Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity

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ACS Chemical Biology

ACS Chemical Biology: Latest Articles (ACS Publications)
Authors: Husna Karaboga, Wentao Huang, Shivangi Srivastava, Scott Widmann, Sridevi Addanki, Kasuni Thawalama Gamage, Zahra Mazhar, Jerry O. Ebalunode, James M. Briggs, Jan-Åke Gustafsson, Carly S. Filgueira, Scott R. Gilbertson, and Chin-Yo Lin
feedproxy.google.com/~r/acs/acbcct/~3/idaNgLj2WoM/acschembio.0c00546

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Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Ramsay E. Beveridge, Heidi Ackerly Wallweber, Avi Ashkenazi, Maureen Beresini, Kevin R. Clark, Paul Gibbons, Elise Ghiro, Susan Kaufman, Alexandre Larivée, Melissa Leblanc, Jean-Philippe Leclerc, Alexandre Lemire, Cuong Ly, Joachim Rudolph, Jacob B. Schwarz, Sanjay Srivastava, Weiru Wang, Liang Zhao, and Marie-Gabrielle Braun
feedproxy.google.com/~r/acs/amclct/~3/h00wEvFFSBk/acsmedchemlett.0c00344

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Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Dennis P. A. Wander, Sabina Y. van der Zanden, Gijsbert A. van der Marel, Herman S. Overkleeft, Jacques Neefjes, and Jeroen D. C. Codée
feedproxy.google.com/~r/acs/jmcmar/~3/KEZdm5b9IXI/acs.jmedchem.0c01191

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Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic Receptors

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Julien Giribaldi, Yves Haufe, Edward R. J. Evans, Muriel Amar, Anna Durner, Casey Schmidt, Adèle Faucherre, Hamid Moha Ou Maati, Christine Enjalbal, Jordi Molgó, Denis Servent, David T. Wilson, Norelle L. Daly, Annette Nicke, and Sébastien Dutertre
feedproxy.google.com/~r/acs/jmcmar/~3/JIy3rPc1W-M/acs.jmedchem.0c00957

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Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “Dual-Soft” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Jens Larsen, Maja Lambert, Henrik Pettersson∞, Thomas Vifian, Mogens Larsen, Anna Ollerstam, Pontus Hegardt, Cecilia Eskilsson, Steen Laursen, Anders Soehoel, Tine Skak-Nielsen, Lene M. Hansen, Nina Ø. Knudsen, Stefan Eirefelt, Morten D. Srensen, Tatiana G. Stilou, and Simon F. Nielsen
feedproxy.google.com/~r/acs/jmcmar/~3/Y64p1Ap7Ljo/acs.jmedchem.0c00797

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Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Žiga Skok, Michaela Barančoková, Ondřej Benek, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašič, Nace Zidar, Lucija Peterlin Mašič, Anamarija Zega, Clare E. M. Stevenson, Julia E. A. Mundy, David M. Lawson, Anthony Maxwell, Danijel Kikelj, and Janez Ilaš
feedproxy.google.com/~r/acs/amclct/~3/kkESQ7vbMXc/acsmedchemlett.0c00416

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