sp2-sp3_coupling

Continuous Flow Enables Metallaphotoredox Catalysis in a Medicinal Chemistry Setting: Accelerated Optimization and Library Execution of a Reductive Coupling between Benzylic Chlorides and Aryl Bromides

Merck
[1]

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  • Z.G. Brill, C.B. Ritts, U.F. Mansoor, and N. Sciammetta, "Continuous Flow Enables Metallaphotoredox Catalysis in a Medicinal Chemistry Setting: Accelerated Optimization and Library Execution of a Reductive Coupling between Benzylic Chlorides and Aryl Bromides", Organic Letters, vol. 22, pp. 410-416, 2019. http://dx.doi.org/10.1021/acs.orglett.9b04117
  • Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile

    [Weix lab, Pfizer]

    [1]
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  • R.J. Perkins, A.J. Hughes, D.J. Weix, and E.C. Hansen, "Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile", Organic Process Research & Development, vol. 23, pp. 1746-1751, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00232
  • Visible‐Light‐Promoted Iron‐Catalyzed C(sp2)–C(sp3) Kumada Cross‐Coupling in Flow

    [Timothy Noel]

    [1]

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  • X. Wei, I. Abdiaj, C. Sambiagio, C. Li, E. Zysman‐Colman, J. Alcázar, and T. Noël, "Visible‐Light‐Promoted Iron‐Catalyzed C(sp 2 )–C(sp 3 ) Kumada Cross‐Coupling in Flow", Angewandte Chemie International Edition, vol. 58, pp. 13030-13034, 2019. http://dx.doi.org/10.1002/anie.201906462
  • Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

    [1]

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  • T.C. Sherwood, H. Xiao, R.G. Bhaskar, E.M. Simmons, S. Zaretsky, M.P. Rauch, R.R. Knowles, and T.G.M. Dhar, "Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light", The Journal of Organic Chemistry, vol. 84, pp. 8360-8379, 2019. http://dx.doi.org/10.1021/acs.joc.9b00432
  • Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides

    [1]

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  • J. Liao, C.H. Basch, M.E. Hoerrner, M.R. Talley, B.P. Boscoe, J.W. Tucker, M.R. Garnsey, and M.P. Watson, "Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides", Organic Letters, vol. 21, pp. 2941-2946, 2019. http://dx.doi.org/10.1021/acs.orglett.9b01014
  • Preparation of Alkyl Indium Reagents by Iodine-Catalyzed Direct Indium Insertion and Their Applications in Cross-Coupling Reactions

    [1]

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  • M. Zhi, B. Chen, W. Deng, X. Chu, T. Loh, and Z. Shen, "Preparation of Alkyl Indium Reagents by Iodine-Catalyzed Direct Indium Insertion and Their Applications in Cross-Coupling Reactions", The Journal of Organic Chemistry, vol. 84, pp. 3017-3023, 2019. http://dx.doi.org/10.1021/acs.joc.9b00204
  • Synthesis of (+)-Vitepyrroloid A and (+)-Vitepyrroloid B by Late-Stage Ni-Catalyzed C(sp2)–C(sp3) Cross-Electrophile Coupling


    [1]

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  • M. Menger, D. Lentz, and M. Christmann, "Synthesis of (+)-Vitepyrroloid A and (+)-Vitepyrroloid B by Late-Stage Ni-Catalyzed C(sp2)–C(sp3) Cross-Electrophile Coupling", The Journal of Organic Chemistry, vol. 83, pp. 6793-6797, 2018. http://dx.doi.org/10.1021/acs.joc.8b00882
  • Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Monofluoroalkyl Halides for Late-Stage Monofluoroalkylation



    [1]

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  • J. Sheng, H. Ni, H. Zhang, K. Zhang, Y. Wang, and X. Wang, "Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Monofluoroalkyl Halides for Late-Stage Monofluoroalkylation", Angewandte Chemie International Edition, vol. 57, pp. 7634-7639, 2018. http://dx.doi.org/10.1002/anie.201803228
  • Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling

    Pfizer, Asymchem & Weix

    [1]

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  • E.C. Hansen, C. Li, S. Yang, D. Pedro, and D.J. Weix, "Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling", The Journal of Organic Chemistry, vol. 82, pp. 7085-7092, 2017. http://dx.doi.org/10.1021/acs.joc.7b01334
  • C(sp3)-C(sp2) cross-coupling of alkylsilicates with borylated aryl bromides – an iterative platform to alkylated aryl- and heteroaryl boronates


    [1]

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  • B.A. Vara, M. Jouffroy, and G.A. Molander, "C(sp3)–C(sp2) cross-coupling of alkylsilicates with borylated aryl bromides – an iterative platform to alkylated aryl- and heteroaryl boronates", Chemical Science, vol. 8, pp. 530-535, 2017. http://dx.doi.org/10.1039/C6SC03236B