boron

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-ß-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

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  • B. Liu, R.E.L. Trout, G. Chu, D. McGarry, R.W. Jackson, J.C. Hamrick, D.M. Daigle, S.M. Cusick, C. Pozzi, F. De Luca, M. Benvenuti, S. Mangani, J. Docquier, W.J. Weiss, D.C. Pevear, L. Xerri, and C.J. Burns, "Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections", Journal of Medicinal Chemistry, vol. 63, pp. 2789-2801, 2019. http://dx.doi.org/10.1021/acs.jmedchem.9b01518
  • De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX


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  • J. Tan, J.J. Grouleff, Y. Jitkova, D.B. Diaz, E.C. Griffith, W. Shao, A.F. Bogdanchikova, G. Poda, A.D. Schimmer, R.E. Lee, and A.K. Yudin, "De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX", Journal of Medicinal Chemistry, vol. 62, pp. 6377-6390, 2019. http://dx.doi.org/10.1021/acs.jmedchem.9b00878
  • Umpolung Reactivity of in Situ Generated Phosphido-Boranes: An Entry to P-Stereogenic Aminophosphine-Boranes

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  • S. Lemouzy, R. Membrat, E. Olivieri, M. Jean, M. Albalat, D. Nuel, L. Giordano, D. Hérault, and G. Buono, "Umpolung Reactivity of in Situ Generated Phosphido-Boranes: An Entry to P-Stereogenic Aminophosphine-Boranes", The Journal of Organic Chemistry, vol. 84, pp. 4551-4557, 2019. http://dx.doi.org/10.1021/acs.joc.9b00333
  • Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

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  • P.Y. Chong, J.B. Shotwell, J. Miller, D.J. Price, A. Maynard, C. Voitenleitner, A. Mathis, S. Williams, J.J. Pouliot, K. Creech, F. Wang, J. Fang, H. Zhang, V.W. Tai, E. Turner, K.M. Kahler, R. Crosby, and A.J. Peat, "Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor", Journal of Medicinal Chemistry, vol. 62, pp. 3254-3267, 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01719
  • Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

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  • R.T. Jacobs, C.S. Lunde, Y.R. Freund, V. Hernandez, X. Li, Y. Xia, D.S. Carter, P.W. Berry, J. Halladay, F. Rock, R. Stefanakis, E. Easom, J.J. Plattner, L. Ford, K.L. Johnston, D.A.N. Cook, R. Clare, A. Cassidy, L. Myhill, H. Tyrer, J. Gamble, A.F. Guimaraes, A. Steven, F. Lenz, A. Ehrens, S.J. Frohberger, M. Koschel, A. Hoerauf, M.P. Hübner, C.W. McNamara, M.A. Bakowski, J.D. Turner, M.J. Taylor, and S.A. Ward, "Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis", Journal of Medicinal Chemistry, vol. 62, pp. 2521-2540, 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01854
  • gem‐Difluorination of Alkenyl N‐methyliminodiacetyl Boronates: Synthesis of α‐ and β‐Difluorinated Alkylboronsgem‐Difluorination of Alkenyl N‐methyliminodiacetyl Boronates: Synthesis of α‐ and β‐Difluorinated Alkylborons


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  • W. Lv, Q. Li, J. Li, Z. Li, E. Lin, D. Tan, Y. Cai, W. Fan, and H. Wang, "gem -Difluorination of Alkenyl N -methyliminodiacetyl Boronates: Synthesis of α- and β-Difluorinated Alkylborons", Angewandte Chemie International Edition, vol. 57, pp. 16544-16548, 2018. http://dx.doi.org/10.1002/anie.201810204
  • Intermolecular Reductive C–N Cross Coupling of Nitroarenes and Boronic Acids by PIII/PV═O Catalysis

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  • T.V. Nykaza, J.C. Cooper, G. Li, N. Mahieu, A. Ramirez, M.R. Luzung, and A.T. Radosevich, "Intermolecular Reductive C–N Cross Coupling of Nitroarenes and Boronic Acids by PIII/PV═O Catalysis", Journal of the American Chemical Society, vol. 140, pp. 15200-15205, 2018. http://dx.doi.org/10.1021/jacs.8b10769