Designing Algorithms To Aid Discovery by Chemical Robots
Lee Cronin Lab
[cite]10.1021/acscentsci.8b00176[/cite]
Radical Chlorodifluoromethylation: Providing a Motif for (Hetero)arene Diversification
[cite]10.1021/acs.orglett.8b01249[/cite]
Synthesis of (+)-Vitepyrroloid A and (+)-Vitepyrroloid B by Late-Stage Ni-Catalyzed C(sp2)–C(sp3) Cross-Electrophile Coupling
[cite]10.1021/acs.joc.8b00882[/cite]
Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Monofluoroalkyl Halides for Late-Stage Monofluoroalkylation
[cite]10.1002/anie.201803228[/cite]
Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids
[cite]10.1021/jacs.8b02650[/cite]
Predicting Reaction Performance in C−N Cross-Coupling Using Machine Learning
[Merck, Abigail G. Doyle]
[cite]10.1126/science.aar5169[/cite]
Protecting Group Free Radical C-H Trifluoromethylation of Peptides
[cite]10.1039/C8SC00368H[/cite]
Deoxyfluorination with Sulfonyl Fluorides: Navigating Reaction Space with Machine Learning
[cite]10.1021/jacs.8b01523[/cite]
Elucidating the Role of the Boronic Esters in the Suzuki–Miyaura Reaction: Structural, Kinetic, and Computational Investigations
from the Scott E. Denmark group
[cite]10.1021/jacs.8b00400[/cite]
Nickel‐Catalyzed Umpolung Arylation of Ambiphilic α‐Bromoalkyl Boronic Esters
[cite]10.1002/anie.201712428[/cite]
Multimetallic Ni- and Pd-Catalyzed Cross-Electrophile Coupling To Form Highly Substituted 1,3-Dienes
[cite]10.1021/jacs.7b13601[/cite]
A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow
[Pfizer]
[cite]10.1126/science.aap9112[/cite]
Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals
Lee Cronin Lab
[cite]10.1126/science.aao3466[/cite]
Tetrahydrobenzo[c]thieno[2,1-e]isothiazole 4-Oxides: Three-Dimensional Heterocycles as Cross-Coupling Building Blocks
[cite]10.1021/acs.orglett.7b03475[/cite]
Dual nickel and Lewis acid catalysis for cross-electrophile coupling: the allylation of aryl halides with allylic alcohols
[cite]10.1039/C7SC03140H[/cite]
Selective Radical Fluorination of Tertiary Alkyl Halides at Room Temperature
[cite]10.1002/anie.201708197[/cite]
Esterification of Carboxylic Acids with Difluoromethyl Diazomethane and Interrupted Esterification with Trifluoromethyl Diazomethane: A Fluorine Effect
[cite]10.1021/acs.orglett.7b02866[/cite]
1-Trifluoromethylisoquinolines from α-Benzylated Tosylmethyl Isocyanide Derivatives in a Modular Approach
[cite]10.1021/acs.orglett.7b02882[/cite]
Nickel(II)-Catalyzed Site-Selective C–H Bond Trifluoromethylation of Arylamine in Water through a Coordinating Activation Strategy
[cite]10.1021/acs.orglett.7b02823[/cite]
Photoredox Enables the Construction of 1,1-Difluoroalkene Carbonyl Mimics
[cite]10.1002/anie.201709487[/cite]
Ketones as directing groups in photocatalytic sp3 C–H fluorination
[cite]10.1039/C7SC02703F[/cite]
Exploiting a “Beast” in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy
[cite]10.1021/jacs.7b07891[/cite]
Difluoromethylation of Carboxylic Acids via the Addition of Difluorinated Phosphorus Ylide to Acyl Chlorides
[cite]10.1021/acs.orglett.7b02601[/cite]
Ex Situ Generation of Sulfuryl Fluoride for the Synthesis of Aryl Fluorosulfates
[cite]10.1021/acs.orglett.7b02522[/cite]