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février 2023 – ChemDigest

Mois : février 2023

Creating and Stabilizing an Oxidized Pd Surface under Reductive Conditions for Photocatalytic Hydrogenation of Aromatic Carbonyls

Par / 28 février 2023 / Non classé

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Journal of the American Chemical Society

Journal of the American Chemical Society: Latest Articles (ACS Publications)
Authors: Wei Qiao, Xing Fan, Weifeng Liu, Fahir Niaz Khan, Dongsheng Zhang, Feiyu Han, Huiyu Yue, Yajiao Li, Nikolaos Dimitratos, Stefania Albonetti, Xiaodong Wen, Yong Yang, Flemming Besenbacher, Yongwang Li, Hans Niemantsverdriet, Haiping Lin, and Ren Su
dx.doi.org/https://doi.org/10.1021/jacs.2c13196

Diversifying Amino Acids and Peptides via Deaminative Reductive Cross-Couplings Leveraging High-Throughput Experimentation

Par / 28 février 2023 / Non classé

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Journal of the American Chemical Society

Journal of the American Chemical Society: Latest Articles (ACS Publications)
Authors: J. Cameron Twitty, Yun Hong, Bria Garcia, Stephanie Tsang, Jennie Liao, Danielle M. Schultz, Jennifer Hanisak, Susan L. Zultanski, Amelie Dion, Dipannita Kalyani, and Mary P. Watson
dx.doi.org/https://doi.org/10.1021/jacs.2c11451

Mechanical Interlocking Enhances the Electrocatalytic Oxygen Reduction Activity and Selectivity of Molecular Copper Complexes

Par / 28 février 2023 / Non classé

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Journal of the American Chemical Society

Journal of the American Chemical Society: Latest Articles (ACS Publications)
Authors: Xiaoyong Mo, Yulin Deng, Samuel Kin-Man Lai, Xutao Gao, Hung-Ling Yu, Kam-Hung Low, Zhengxiao Guo, Heng-Liang Wu, Ho Yu Au-Yeung, and Edmund C. M. Tse
dx.doi.org/https://doi.org/10.1021/jacs.2c10988

Coaxially Conductive Organic Wires Through Self-Assembly

Par / 28 février 2023 / Non classé

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Journal of the American Chemical Society

Journal of the American Chemical Society: Latest Articles (ACS Publications)
Authors: Shayan Louie, Yu Zhong, Si Tong Bao, Cedric Schaack, Alvaro Montoya, Zexin Jin, Nicholas M. Orchanian, Yang Liu, Wenrui Lei, Kelsey Harrison, James Hone, Alexander Angerhofer, Austin M. Evans, and Colin P. Nuckolls
dx.doi.org/https://doi.org/10.1021/jacs.2c12437

Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach

Par / 28 février 2023 / medchem

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Minh H. Nguyen, Hai-Fen Ye, Yao Xu, Lisa Truong, April Horsey, Peng Zhao, Evan D. Styduhar, Michelle Frascella, Lynn Leffet, Kelly Federowicz, Elham Behshad, Anlai Wang, Ke Zhang, Michael R. Witten, Chao Qi, Ravi Jalluri, Cheng-Tsung Lai, Onur Atasoylu, Jennifer J. Harris, Rodrigo Hess, Luping Lin, Guofeng Zhang, Maryanne Covington, Sharon Diamond, Wenqing Yao, and Oleg Vechorkin
dx.doi.org/http://dx.doi.org/10.1021/acsmedchemlett.3c00003

A Family of Bisnaphthyl C2‑Symmetric and Asymmetric Clefts: Synthesis, Solid-State Structure, and Calculation of the Interplanar Angle

Par / 28 février 2023 / Non classé

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The Journal of Organic Chemistry

The Journal of Organic Chemistry: Latest Articles (ACS Publications)
Authors: Gazalah S. Mohammed Elgadi, Mark R. J. Elsegood, Miheal Patel, Paulo. A. Netz, Tiago E. de Oliveira, and Marc C. Kimber
dx.doi.org/https://doi.org/10.1021/acs.joc.2c03002

Synthesis, Isolation, and Characterization of Two Cationic Organobismuth(II) Pincer Complexes Relevant in Radical Redox Chemistry

Par / 28 février 2023 / Non classé

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Journal of the American Chemical Society

Journal of the American Chemical Society: Latest Articles (ACS Publications)
Authors: Xiuxiu Yang, Edward J. Reijerse, Nils Nöthling, Daniel J. SantaLucia, Markus Leutzsch, Alexander Schnegg, and Josep Cornella
dx.doi.org/https://doi.org/10.1021/jacs.2c12564

Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus

Par / 28 février 2023 / chemical_biology

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ACS Chemical Biology

ACS Chemical Biology: Latest Articles (ACS Publications)
Authors: Eric Bryan, Edgar Ferrer-González, Hye Yeon Sagong, Junso Fujita, Lilly Mark, Malvika Kaul, Edmond J. LaVoie, Hiroyoshi Matsumura, and Daniel S. Pilch
dx.doi.org/https://doi.org/10.1021/acschembio.2c00934

Structural Dynamics-Driven Discovery of Anticancer and Antimetastatic Effects of Diltiazem and Glibenclamide Targeting Urokinase Receptor

Par / 28 février 2023 / medchem

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Yang Zhou, Meiru Song, Daoqing Xie, Shufeng Yan, Shujuan Yu, Song Xie, Meiqin Cai, Hanlin Li, Le Shang, Longguang Jiang, Cai Yuan, Mingdong Huang, Jinyu Li, and Peng Xu
dx.doi.org/http://dx.doi.org/10.1021/acs.jmedchem.2c01663

Catalytic Asymmetric Conjugate Reduction

Par / 28 février 2023 / Non classé
Catalytic Asymmetric Conjugate Reduction

Asymmetric conjugate reduction (ACR) reactions have emerged over the last decades as straightforward and powerful transformations that provide direct access to chiral building blocks bearing ubiquitous trisubstituted stereocenters. This comprehensive Review focuses on the three areas of catalysis that contributed the most to the development of ACR chemistry: transition-metal, organic, and enzymatic catalysis.

Abstract

Enantioselective reduction reactions are privileged transformations for the construction of trisubstituted stereogenic centers. While these include established synthetic strategies, such as asymmetric hydrogenation, methods based on the enantioselective addition of hydridic reagents to electrophilic prochiral substrates have also gained importance. In this context, the asymmetric conjugate reduction (ACR) of α,β-unsaturated compounds has become a convenient approach for the synthesis of chiral compounds with trisubstituted stereocenters in α-, β-, or γ-position to electron-withdrawing functional groups. Because such activating groups are diverse and amenable of further derivatizations, ACRs provide a general and powerful synthetic entry towards a variety of valuable chiral building blocks. This Review provides a comprehensive collection of catalytic ACR methods involving transition-metal, organic, and enzymatic catalysis since its first versions dating back to the late 1970s.

Wiley: Angewandte Chemie International Edition: Table of Contents
Authors: Giovanni Lonardi, Riccardo Parolin, Giulia Licini, Manuel Orlandi
onlinelibrary.wiley.com/doi/10.1002/anie.202216649

Solvent‐free Synthesis of Multi‐Module Pore‐Space‐Partitioned Metal‐Organic Frameworks for Gas Separation

Par / 28 février 2023 / Non classé
Solvent-free Synthesis of Multi-Module Pore-Space-Partitioned Metal-Organic Frameworks for Gas Separation

The convergence of the multi-module concept and solvent-free synthesis method has led to the synthesis of super-stable MOFs by a route free from additive, modulator, solvent, or activation. They combine the advantages of structural complexity and green chemistry and show good C2H2/CO2 separation performance.

Abstract

Multi-module design of framework materials with multiple distinct building blocks has attracted much attention because such materials are more amenable to compositional and geometrical tuning and thus offer more opportunities for property optimization. Few examples are known that use environmentally friendly and cost-effective solvent-free method to synthesize such materials. Here, we report the use of solvent-free method (also modulator-free) to synthesize a series of multi-module MOFs with high stability and separation property for C2H2/CO2. The synthesis only requires simple mixing of reactants and short reaction time (2 h). Highly porous and stable materials can be made without any post-synthetic activation. The success of solvent-free synthesis of multi-module MOFs reflects the synergy between different modules, resulting in stable pore-partitioned materials, despite the fact that other competitive crystallization pathways with simpler framework compositions also exist.

Wiley: Angewandte Chemie International Edition: Table of Contents
Authors: Yuchen Xiao, Yichong Chen, Anh N. Hong, Xianhui Bu, Pingyun Feng
onlinelibrary.wiley.com/doi/10.1002/anie.202300721

Reversible Single Electron Redox Steps Convert Polycycles with a C3P3 Core to a Planar Triphosphinine

Par / 28 février 2023 / Non classé
Reversible Single Electron Redox Steps Convert Polycycles with a C3P3 Core to a Planar Triphosphinine

Reaction of the biradicaloid IDP with trityl phosphaalkyne affords polycyclic compounds with a formally dianionic C3P3 core, which are in a dynamic equilibrium. The reversible, stepwise oxidation by two electrons leads to a planar triphosphinine with an aromatic 6π-electron system. A monocyclic 7π-electron could be isolated as intermediate.

Abstract

Reaction of the imidazolium-stabilized diphosphete-diide IDP with trityl phosphaalkyne affords a mixture which contains the molecules 1 a and 1 b with a central C3P3 core, which formally carries a two-fold negative charge. In order to avoid the formation of an antiaromatic 8π electron system within a conjugated dianionic six-membered [C3P3]2− ring, 1 a adopts a bicyclic [3.1.0] and 1 b a tricyclic [2.2.0.0] structure which are in a dynamic equilibrium. 1 a, b can be reversibly oxidized to a triphosphinine dication [5]2+ with a central flat aromatic six-membered C3P3 ring. This two-electron redox reaction occurs in two single-electron transfer steps via the 7π-radical cation [4]⋅+, which could also be isolated and fully characterized. The profound reversible structural change observed for the two-electron redox couple [5]2+/1 a, b is in sharp contrast to the C6H6/[C6H6]2− couple, which undergoes only a modest structural deformation.

Wiley: Angewandte Chemie International Edition: Table of Contents
Authors: Peter Coburger, Clara Schweinzer, Zhongshu Li, Hansjörg Grützmacher
onlinelibrary.wiley.com/doi/10.1002/anie.202214548