Mois : janvier 2020

Difluoroacetaldehyde N‐Triftosylhydrazone (DFHZ‐Tfs) as a Bench‐Stable Crystalline Diazo Surrogate for Diazoacetaldehyde and Difluorodiazoethane


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  • Y. Ning, X. Zhang, Y. Gai, Y. Dong, P. Sivaguru, Y. Wang, B.R.P. Reddy, G. Zanoni, and X. Bi, "Difluoroacetaldehyde N ‐Triftosylhydrazone (DFHZ‐Tfs) as a Bench‐Stable Crystalline Diazo Surrogate for Diazoacetaldehyde and Difluorodiazoethane", Angewandte Chemie International Edition, vol. 59, pp. 6473-6481, 2020. http://dx.doi.org/10.1002/anie.202000119
  • Human Body-on-Chip platform enables in vitro prediction of drug behaviors in humans

    3 insightful articles on the possibility to miniaturize organism testing through miniaturized models:

    Overview at the Wyss Institute
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  • A. Herland, B.M. Maoz, D. Das, M.R. Somayaji, R. Prantil-Baun, R. Novak, M. Cronce, T. Huffstater, S.S.F. Jeanty, M. Ingram, A. Chalkiadaki, D. Benson Chou, S. Marquez, A. Delahanty, S. Jalili-Firoozinezhad, Y. Milton, A. Sontheimer-Phelps, B. Swenor, O. Levy, K.K. Parker, A. Przekwas, and D.E. Ingber, "Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips", Nature Biomedical Engineering, vol. 4, pp. 421-436, 2020. http://dx.doi.org/10.1038/s41551-019-0498-9
  • R. Novak, M. Ingram, S. Marquez, D. Das, A. Delahanty, A. Herland, B.M. Maoz, S.S.F. Jeanty, M.R. Somayaji, M. Burt, E. Calamari, A. Chalkiadaki, A. Cho, Y. Choe, D.B. Chou, M. Cronce, S. Dauth, T. Divic, J. Fernandez-Alcon, T. Ferrante, J. Ferrier, E.A. FitzGerald, R. Fleming, S. Jalili-Firoozinezhad, T. Grevesse, J.A. Goss, T. Hamkins-Indik, O. Henry, C. Hinojosa, T. Huffstater, K. Jang, V. Kujala, L. Leng, R. Mannix, Y. Milton, J. Nawroth, B.A. Nestor, C.F. Ng, B. O’Connor, T. Park, H. Sanchez, J. Sliz, A. Sontheimer-Phelps, B. Swenor, G. Thompson, G.J. Touloumes, Z. Tranchemontagne, N. Wen, M. Yadid, A. Bahinski, G.A. Hamilton, D. Levner, O. Levy, A. Przekwas, R. Prantil-Baun, K.K. Parker, and D.E. Ingber, "Robotic fluidic coupling and interrogation of multiple vascularized organ chips", Nature Biomedical Engineering, vol. 4, pp. 407-420, 2020. http://dx.doi.org/10.1038/s41551-019-0497-x
  • Iridium‐Catalyzed Silylation of Five‐Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl‐Imidazoline Ligand


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  • C. Karmel, C.Z. Rubel, E.V. Kharitonova, and J.F. Hartwig, "Iridium‐Catalyzed Silylation of Five‐Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl‐Imidazoline Ligand", Angewandte Chemie International Edition, vol. 59, pp. 6074-6081, 2020. http://dx.doi.org/10.1002/anie.201916015
  • Increasing Complexity: A Practical Synthetic Approach to Three‐Dimensional, Cyclic Sulfoximines and First Insights into Their in vitro Properties

    Bayer:

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  • E. Boulard, V. Zibulski, L. Oertel, P. Lienau, M. Schäfer, U. Ganzer, and U. Lücking, "Increasing Complexity: A Practical Synthetic Approach to Three‐Dimensional, Cyclic Sulfoximines and First Insights into Their in Vitro Properties", Chemistry – A European Journal, vol. 26, pp. 4378-4388, 2020. http://dx.doi.org/10.1002/chem.201905461
  • 18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides

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  • C.W. Kee, O. Tack, F. Guibbal, T.C. Wilson, P.G. Isenegger, M. Imiołek, S. Verhoog, M. Tilby, G. Boscutti, S. Ashworth, J. Chupin, R. Kashani, A.W.J. Poh, J.K. Sosabowski, S. Macholl, C. Plisson, B. Cornelissen, M.C. Willis, J. Passchier, B.G. Davis, and V. Gouverneur, "18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides", Journal of the American Chemical Society, vol. 142, pp. 1180-1185, 2020. http://dx.doi.org/10.1021/jacs.9b11709