Mois : octobre 2019

High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides

[GSK]
[1]

  • J. Becica, D.P. Hruszkewycz, J.E. Steves, J.M. Elward, D.C. Leitch, and G.E. Dobereiner, "High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides", Organic Letters, vol. 21, pp. 8981-8986, 2019. http://dx.doi.org/10.1021/acs.orglett.9b03380
  • Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace

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  • J. Frackenpohl, L. Schneider, L.J. Decker, J. Dittgen, F. Fenkl, C. Fischer, J. Franke, J. Freigang, R. Getachew, S.M. Gonzalez Fernandez-Nino, H. Helmke, M.J. Hills, S. Hohmann, J. Kleemann, K. Kurowski, G. Lange, P. Luemmen, N. Meyering, F. Poree, D. Schmutzler, and S. Wrede, "Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace", Bioorganic & Medicinal Chemistry, vol. 27, pp. 115142, 2019. http://dx.doi.org/10.1016/j.bmc.2019.115142
  • Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes

    Enamine chemists reported a comprehensive study of regioselective [3 + 2] cycloaddition reactions – an efficient approach towards 3,5-disubstituted isoxazole building blocks bearing mono-, di- or trifluoromethyl substituents. More than 100 derivatives were obtained on up to 130 g scale, and multigram quantities of representative examples are available from EnamineStore at the isoxazole library
    [1]

  • B.A. Chalyk, K.V. Hrebeniuk, Y.V. Fil, K.S. Gavrilenko, A.B. Rozhenko, B.V. Vashchenko, O.V. Borysov, A.V. Biitseva, P.S. Lebed, I. Bakanovych, Y.S. Moroz, and O.O. Grygorenko, "Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes", The Journal of Organic Chemistry, vol. 84, pp. 15877-15899, 2019. http://dx.doi.org/10.1021/acs.joc.9b02264
  • Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

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  • T.S. Lou, S.W. Bagley, and M.C. Willis, "Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents", Angewandte Chemie International Edition, vol. 58, pp. 18859-18863, 2019. http://dx.doi.org/10.1002/anie.201910871
  • Preparation of 2-(2H-Tetrazol-2-yl)benzoic Acids via Regioselective Cu(I) Catalyzed N2 Arylation of Tetrazole

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  • Z.J. Song, P. Maligres, C. Molinaro, G. Humphrey, J. Fritzen, J. Wilson, and Y. Chen, "Preparation of 2-(2H-Tetrazol-2-yl)benzoic Acids via Regioselective Cu(I) Catalyzed N2 Arylation of Tetrazole", Organic Process Research & Development, vol. 23, pp. 2354-2361, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00243