Mois : juin 2019

De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX


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  • J. Tan, J.J. Grouleff, Y. Jitkova, D.B. Diaz, E.C. Griffith, W. Shao, A.F. Bogdanchikova, G. Poda, A.D. Schimmer, R.E. Lee, and A.K. Yudin, "De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX", Journal of Medicinal Chemistry, vol. 62, pp. 6377-6390, 2019. http://dx.doi.org/10.1021/acs.jmedchem.9b00878
  • Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines


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  • E. Duchamp, B.D. Simard, and S. Hanessian, "Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines", Organic Letters, vol. 21, pp. 6593-6596, 2019. http://dx.doi.org/10.1021/acs.orglett.9b01842
  • Data-Rich Experimentation Enables Palladium-Catalyzed Couplings of Piperidines and Five-Membered (Hetero)aromatic Electrophiles

    (Merck & Co.)

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  • A.C. Sather, and T.A. Martinot, "Data-Rich Experimentation Enables Palladium-Catalyzed Couplings of Piperidines and Five-Membered (Hetero)aromatic Electrophiles", Organic Process Research & Development, vol. 23, pp. 1725-1739, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00233
  • Intramolecular Homolytic Substitution Enabled by Photoredox Catalysis: Sulfur, Phosphorus, and Silicon Heterocycle Synthesis from Aryl Halides


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  • A.F. Garrido-Castro, N. Salaverri, M.C. Maestro, and J. Alemán, "Intramolecular Homolytic Substitution Enabled by Photoredox Catalysis: Sulfur, Phosphorus, and Silicon Heterocycle Synthesis from Aryl Halides", Organic Letters, vol. 21, pp. 5295-5300, 2019. http://dx.doi.org/10.1021/acs.orglett.9b01911
  • Structure Validation of Complex Natural Products: Time to Change the Paradigm. What did Synthesis of Alstofolinine A Prove?


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  • A.G. Kutateladze, and T. Holt, "Structure Validation of Complex Natural Products: Time to Change the Paradigm. What did Synthesis of Alstofolinine A Prove?", The Journal of Organic Chemistry, vol. 84, pp. 8297-8299, 2019. http://dx.doi.org/10.1021/acs.joc.9b00969
  • Olefin Amine (OLA) Reagents for the Synthesis of Bridged Bicyclic and Spirocyclic Saturated N-Heterocycles by Catalytic Hydrogen Atom Transfer (HAT) Reactions


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  • Y. Wang, and J.W. Bode, "Olefin Amine (OLA) Reagents for the Synthesis of Bridged Bicyclic and Spirocyclic Saturated N-Heterocycles by Catalytic Hydrogen Atom Transfer (HAT) Reactions", Journal of the American Chemical Society, vol. 141, pp. 9739-9745, 2019. http://dx.doi.org/10.1021/jacs.9b05074