Mois : avril 2019

Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate


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  • C. Stueckler, P. Hermsen, B. Ritzen, M. Vasiloiu, P. Poechlauer, S. Steinhofer, A. Pelz, C. Zinganell, U. Felfer, S. Boyer, M. Goldbach, A. de Vries, T. Pabst, G. Winkler, V. LaVopa, S. Hecker, and C. Schuster, "Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate", Organic Process Research & Development, vol. 23, pp. 1069-1077, 2019. http://dx.doi.org/10.1021/acs.oprd.8b00340
  • Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents

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  • R. Shinohara, M. Morita, N. Ogawa, and Y. Kobayashi, "Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents", Organic Letters, vol. 21, pp. 3247-3251, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00976
  • Practical and regioselective amination of arenes using alkyl amines

    formation of a highly polarized, aminium radical cation enables direct C–H amination, allowing the coupling of an exceptionally broad range of alkyl amines and arenes
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  • A. Ruffoni, F. Juliá, T..D. Svejstrup, A..J. McMillan, J..J. Douglas, and D. Leonori, "Practical and regioselective amination of arenes using alkyl amines", Nature Chemistry, vol. 11, pp. 426-433, 2019. http://dx.doi.org/10.1038/s41557-019-0254-5