Mois : février 2019

Acoustic Droplet Ejection Enabled Automated Reaction Scouting

[Dömling lab with Astra-Zeneca]

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  • Y. Wang, S. Shaabani, M. Ahmadianmoghaddam, L. Gao, R. Xu, K. Kurpiewska, J. Kalinowska-Tluscik, J. Olechno, R. Ellson, M. Kossenjans, V. Helan, M. Groves, and A. Dömling, "Acoustic Droplet Ejection Enabled Automated Reaction Scouting", ACS Central Science, vol. 5, pp. 451-457, 2019. http://dx.doi.org/10.1021/acscentsci.8b00782
  • Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

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  • R.T. Jacobs, C.S. Lunde, Y.R. Freund, V. Hernandez, X. Li, Y. Xia, D.S. Carter, P.W. Berry, J. Halladay, F. Rock, R. Stefanakis, E. Easom, J.J. Plattner, L. Ford, K.L. Johnston, D.A.N. Cook, R. Clare, A. Cassidy, L. Myhill, H. Tyrer, J. Gamble, A.F. Guimaraes, A. Steven, F. Lenz, A. Ehrens, S.J. Frohberger, M. Koschel, A. Hoerauf, M.P. Hübner, C.W. McNamara, M.A. Bakowski, J.D. Turner, M.J. Taylor, and S.A. Ward, "Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis", Journal of Medicinal Chemistry, vol. 62, pp. 2521-2540, 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01854
  • Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space

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  • S.V. Zasukha, V.M. Timoshenko, A.A. Tolmachev, V.O. Pivnytska, O. Gavrylenko, S. Zhersh, Y. Shermolovich, and O.O. Grygorenko, "Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space", Chemistry – A European Journal, vol. 25, pp. 6928-6940, 2019. http://dx.doi.org/10.1002/chem.201900440
  • Copper-Catalyzed Asymmetric Conjugate Additions of Bis(pinacolato)diboron and Dimethylzinc to Acyl-N-methylimidazole Michael Acceptors: A Highly Stereoselective Unified Strategy for 1,3,5,…n (OH, Me) Motif Synthesis

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  • J. Lauberteaux, C. Crévisy, O. Baslé, R.M. de Figueiredo, M. Mauduit, and J. Campagne, "Copper-Catalyzed Asymmetric Conjugate Additions of Bis(pinacolato)diboron and Dimethylzinc to Acyl-N-methylimidazole Michael Acceptors: A Highly Stereoselective Unified Strategy for 1,3,5,...n (OH, Me) Motif Synthesis", Organic Letters, vol. 21, pp. 1872-1876, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00479
  • Selection of cost-effective yet chemically diverse pathways from the networks of computer-generated retrosynthetic plans

    Further developments of the “computer-aided synthesis planning” software Chematica (bought by Merck and further developed as ‘Synthia’):

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  • T. Badowski, K. Molga, and B.A. Grzybowski, "Selection of cost-effective yet chemically diverse pathways from the networks of computer-generated retrosynthetic plans", Chemical Science, vol. 10, pp. 4640-4651, 2019. http://dx.doi.org/10.1039/C8SC05611K
  • Siladifluoromethylation and Deoxo-trifluoromethylation of PV–H Compounds with TMSCF3: Route to PV–CF2– Transfer Reagents and P–CF3 Compounds

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  • V. Krishnamurti, C. Barrett, and G.K.S. Prakash, "Siladifluoromethylation and Deoxo-trifluoromethylation of PV–H Compounds with TMSCF3: Route to PV–CF2– Transfer Reagents and P–CF3 Compounds", Organic Letters, vol. 21, pp. 1526-1529, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00381
  • Reaction of Nitrogen‐Radicals with Organometallics Under Ni‐Catalysis: N‐Arylations and Amino‐Functionalization Cascades

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  • L. Angelini, J. Davies, M. Simonetti, L. Malet Sanz, N.S. Sheikh, and D. Leonori, "Reaction of Nitrogen‐Radicals with Organometallics Under Ni‐Catalysis: N‐Arylations and Amino‐Functionalization Cascades", Angewandte Chemie International Edition, vol. 58, pp. 5003-5007, 2019. http://dx.doi.org/10.1002/anie.201900510
  • Preparation of Alkyl Indium Reagents by Iodine-Catalyzed Direct Indium Insertion and Their Applications in Cross-Coupling Reactions

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  • M. Zhi, B. Chen, W. Deng, X. Chu, T. Loh, and Z. Shen, "Preparation of Alkyl Indium Reagents by Iodine-Catalyzed Direct Indium Insertion and Their Applications in Cross-Coupling Reactions", The Journal of Organic Chemistry, vol. 84, pp. 3017-3023, 2019. http://dx.doi.org/10.1021/acs.joc.9b00204