Mois : janvier 2019

Rhodium-Catalyzed Aldehyde Arylation via Formate-Mediated Transfer Hydrogenation: Beyond Metallic Reductants in Grignard/Nozaki–Hiyami–Kishi-Type Addition

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  • R.A. Swyka, W. Zhang, J. Richardson, J.C. Ruble, and M.J. Krische, "Rhodium-Catalyzed Aldehyde Arylation via Formate-Mediated Transfer Hydrogenation: Beyond Metallic Reductants in Grignard/Nozaki–Hiyami–Kishi-Type Addition", Journal of the American Chemical Society, vol. 141, pp. 1828-1832, 2019. http://dx.doi.org/10.1021/jacs.8b13652
  • Defining and Exploiting Hypersensitivity Hotspots to Facilitate Abscisic Acid Agonist Optimization

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  • D. Elzinga, E. Sternburg, D. Sabbadin, M. Bartsch, S. Park, A. Vaidya, A. Mosquna, A. Kaundal, S. Wendeborn, M. Lachia, F.V. Karginov, and S.R. Cutler, "Defining and Exploiting Hypersensitivity Hotspots to Facilitate Abscisic Acid Agonist Optimization", ACS Chemical Biology, vol. 14, pp. 332-336, 2019. http://dx.doi.org/10.1021/acschembio.8b00955
  • Dual Photoredox/Copper Catalysis for the Remote C(sp3)−H Functionalization of Alcohols and Alkyl Halides by N‐Alkoxypyridinium Salts


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  • X. Bao, Q. Wang, and J. Zhu, "Dual Photoredox/Copper Catalysis for the Remote C(sp3 )−H Functionalization of Alcohols and Alkyl Halides by N -Alkoxypyridinium Salts", Angewandte Chemie International Edition, vol. 58, pp. 2139-2143, 2019. http://dx.doi.org/10.1002/anie.201813356
  • Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)


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  • J. Hu, B. Hu, M. Wang, F. Xu, B. Miao, C. Yang, M. Wang, Z. Liu, D.F. Hayes, K. Chinnaswamy, J. Delproposto, J. Stuckey, and S. Wang, "Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)", Journal of Medicinal Chemistry, vol. 62, pp. 1420-1442, 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01572
  • Development of Universal, Automated Sample Acquisition, Preparation, and Delivery Devices and Methods for Pharmaceutical Applications

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  • G.R. Lambertus, L.P. Webster, T.M. Braden, B.M. Campbell, J. McClary Groh, T.D. Maloney, P. Milenbaugh, R.D. Spencer, W. Sun, and M.D. Johnson, "Development of Universal, Automated Sample Acquisition, Preparation, and Delivery Devices and Methods for Pharmaceutical Applications", Organic Process Research & Development, vol. 23, pp. 189-210, 2018. http://dx.doi.org/10.1021/acs.oprd.8b00280