safety

Safety First: A Recent Case of a Dichloromethane Injection Injury

Par David B / 26 février 2020 6 mars 2020 / safety

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S. Vidal, "Safety First: A Recent Case of a Dichloromethane Injection Injury", ACS Central Science, vol. 6, pp. 83-86, 2020. http://dx.doi.org/10.1021/acscentsci.0c00100

Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU

Par David B / 31 décembre 2019 20 janvier 2020 / amide_bond​_formation, safety

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K.J. McKnelly, W. Sokol, and J.S. Nowick, "Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU", The Journal of Organic Chemistry, vol. 85, pp. 1764-1768, 2019. http://dx.doi.org/10.1021/acs.joc.9b03280

Potential Safety Hazards Associated with Pd-Catalyzed Cross-Coupling Reactions

Par David B / 12 novembre 2019 16 décembre 2019 / catalysis, safety, up-scaling

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Q. Yang, N.R. Babij, and S. Good, "Potential Safety Hazards Associated with Pd-Catalyzed Cross-Coupling Reactions", Organic Process Research & Development, vol. 23, pp. 2608-2626, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00377

Can Dip Strips Really Test for Peroxides in Organic Solvents Semiquantitatively?

Par David B / 1 novembre 2019 16 décembre 2019 / safety

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Y. Jiang, X. Song, N. Hou, and C. Pan, "Can Dip Strips Really Test for Peroxides in Organic Solvents Semiquantitatively?", Organic Process Research & Development, vol. 23, pp. 2538-2542, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00321

Preparation of 2-(2H-Tetrazol-2-yl)benzoic Acids via Regioselective Cu(I) Catalyzed N2 Arylation of Tetrazole

Par David B / 14 octobre 2019 25 octobre 2019 / heterocycles, medchem, safety, up-scaling

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Z.J. Song, P. Maligres, C. Molinaro, G. Humphrey, J. Fritzen, J. Wilson, and Y. Chen, "Preparation of 2-(2H-Tetrazol-2-yl)benzoic Acids via Regioselective Cu(I) Catalyzed N2 Arylation of Tetrazole", Organic Process Research & Development, vol. 23, pp. 2354-2361, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00243

Practical Application of the Aqueous ‘Sulfonyl-Azide-Free’ (SAFE) Diazo Transfer Protocol to Less α-C–H Acidic Ketones and Esters

Par David B / 28 août 2019 24 octobre 2019 / mechanism, safety

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D. Dar’in, G. Kantin, and M. Krasavin, "Practical Application of the Aqueous ‘Sulfonyl-Azide-Free’ (SAFE) Diazo Transfer Protocol to Less α-C–H Acidic Ketones and Esters", Synthesis, vol. 51, pp. 4284-4290, 2019. http://dx.doi.org/10.1055/s-0039-1690613

Explosion Hazards of Sodium Hydride in DMSO, DMF, and DMAc

Par admin / 10 août 2019 12 août 2019 / safety, up-scaling

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Q. Yang, M. Sheng, J.J. Henkelis, S. Tu, E. Wiensch, H. Zhang, Y. Zhang, C. Tucker, and D.E. Ejeh, "Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, N,N-Dimethylformamide, and N,N-Dimethylacetamide", Organic Process Research & Development, vol. 23, pp. 2210-2217, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00276

Identification of Significant Process Safety Risks in the Preparation of Methyl-N-cyanocarbamate

Par admin / 3 juillet 2019 5 août 2019 / safety, up-scaling

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K. Emerson, D. Muzzio, and E. Fisher, "Identification of Significant Process Safety Risks in the Preparation of Methyl-N-cyanocarbamate", Organic Process Research & Development, vol. 23, pp. 1352-1358, 2019. http://dx.doi.org/10.1021/acs.oprd.9b00103

Development and Demonstration of a Safer Protocol for the Synthesis of 5-Aryltetrazoles from Aryl Nitriles

Par admin / 17 février 2017 12 août 2019 / flow_chemi​stry, heterocycles, safety, up-scaling

[tetrazoles, Bristol-Myers Squibb]

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D.S. Treitler, S. Leung, and M. Lindrud, "Development and Demonstration of a Safer Protocol for the Synthesis of 5-Aryltetrazoles from Aryl Nitriles", Organic Process Research & Development, vol. 21, pp. 460-467, 2017. http://dx.doi.org/10.1021/acs.oprd.7b00016

Two Approaches to the Chemical Development and Large-Scale Preparation of a Pyrimidyl Tetrazole Intermediate

Par admin / 8 juin 2016 12 août 2019 / heterocycles, safety, up-scaling

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P. Mullens, E. Cleator, M. McLaughlin, B. Bishop, J. Edwards, A. Goodyear, T. Andreani, Y. Jin, J. Kong, H. Li, M. Williams, and M. Zacuto, "Two Approaches to the Chemical Development and Large-Scale Preparation of a Pyrimidyl Tetrazole Intermediate", Organic Process Research & Development, vol. 20, pp. 1075-1087, 2016. http://dx.doi.org/10.1021/acs.oprd.6b00136

Hydrolysis of Phosphoryl Trichloride (POCl3): Characterization, in Situ Detection, and Safe Quenching of Energetic Metastable Intermediates

Par admin / 23 août 2010 12 août 2019 / safety, up-scaling

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M.M. Achmatowicz, O.R. Thiel, J.T. Colyer, J. Hu, M.V.S. Elipe, J. Tomaskevitch, J.S. Tedrow, and R.D. Larsen, "Hydrolysis of Phosphoryl Trichloride (POCl3): Characterization, in Situ Detection, and Safe Quenching of Energetic Metastable Intermediates", Organic Process Research & Development, vol. 14, pp. 1490-1500, 2010. http://dx.doi.org/10.1021/op1001484

Diazidomethane Explosion

Par admin / 21 août 2008 12 août 2019 / safety

[Notes on a safety incident involving azides at Alcon Research, Ltd.]

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R.E. Conrow, and W.D. Dean, "Diazidomethane Explosion", Organic Process Research & Development, vol. 12, pp. 1285-1286, 2008. http://dx.doi.org/10.1021/op8000977

An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent

Par admin / 9 avril 2003 12 août 2019 / fluorine, organomet_chem, safety

[safety hazards associated with trifluoromethylaryl Grignard reagents, Merck]

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J.L. Leazer,, R. Cvetovich, F. Tsay, U. Dolling, T. Vickery, and D. Bachert, "An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent", The Journal of Organic Chemistry, vol. 68, pp. 3695-3698, 2003. http://dx.doi.org/10.1021/jo026903n