Two Approaches to the Chemical Development and Large-Scale Preparation of a Pyrimidyl Tetrazole Intermediate

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  • P. Mullens, E. Cleator, M. McLaughlin, B. Bishop, J. Edwards, A. Goodyear, T. Andreani, Y. Jin, J. Kong, H. Li, M. Williams, and M. Zacuto, "Two Approaches to the Chemical Development and Large-Scale Preparation of a Pyrimidyl Tetrazole Intermediate", Organic Process Research & Development, vol. 20, pp. 1075-1087, 2016. http://dx.doi.org/10.1021/acs.oprd.6b00136

    • Hydrolysis of Phosphoryl Trichloride (POCl3): Characterization, in Situ Detection, and Safe Quenching of Energetic Metastable Intermediates

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    [1]

  • M.M. Achmatowicz, O.R. Thiel, J.T. Colyer, J. Hu, M.V.S. Elipe, J. Tomaskevitch, J.S. Tedrow, and R.D. Larsen, "Hydrolysis of Phosphoryl Trichloride (POCl3): Characterization, in Situ Detection, and Safe Quenching of Energetic Metastable Intermediates", Organic Process Research & Development, vol. 14, pp. 1490-1500, 2010. http://dx.doi.org/10.1021/op1001484

    • An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent

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    [safety hazards associated with trifluoromethylaryl Grignard reagents, Merck]

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  • J.L. Leazer,, R. Cvetovich, F. Tsay, U. Dolling, T. Vickery, and D. Bachert, "An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent", The Journal of Organic Chemistry, vol. 68, pp. 3695-3698, 2003. http://dx.doi.org/10.1021/jo026903n