Merck
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  • Z.G. Brill, C.B. Ritts, U.F. Mansoor, and N. Sciammetta, "Continuous Flow Enables Metallaphotoredox Catalysis in a Medicinal Chemistry Setting: Accelerated Optimization and Library Execution of a Reductive Coupling between Benzylic Chlorides and Aryl Bromides", Organic Letters, vol. 22, pp. 410-416, 2019. http://dx.doi.org/10.1021/acs.orglett.9b04117
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  • B.A. Chalyk, A. Khutorianskyi, A. Lysenko, Y. Fil, Y.O. Kuchkovska, K.S. Gavrilenko, I. Bakanovych, Y.S. Moroz, A.O. Gorlova, and O.O. Grygorenko, "Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles", The Journal of Organic Chemistry, vol. 84, pp. 15212-15225, 2019. http://dx.doi.org/10.1021/acs.joc.9b02258
  • Enamine chemists reported a comprehensive study of regioselective [3 + 2] cycloaddition reactions – an efficient approach towards 3,5-disubstituted isoxazole building blocks bearing mono-, di- or trifluoromethyl substituents. More than 100 derivatives were obtained on up to 130 g scale, and multigram quantities of representative examples are available from EnamineStore at the isoxazole library
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  • B.A. Chalyk, K.V. Hrebeniuk, Y.V. Fil, K.S. Gavrilenko, A.B. Rozhenko, B.V. Vashchenko, O.V. Borysov, A.V. Biitseva, P.S. Lebed, I. Bakanovych, Y.S. Moroz, and O.O. Grygorenko, "Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes", The Journal of Organic Chemistry, vol. 84, pp. 15877-15899, 2019. http://dx.doi.org/10.1021/acs.joc.9b02264