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  • C. Stueckler, P. Hermsen, B. Ritzen, M. Vasiloiu, P. Poechlauer, S. Steinhofer, A. Pelz, C. Zinganell, U. Felfer, S. Boyer, M. Goldbach, A. de Vries, T. Pabst, G. Winkler, V. LaVopa, S. Hecker, and C. Schuster, "Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate", Organic Process Research & Development, vol. 23, pp. 1069-1077, 2019. http://dx.doi.org/10.1021/acs.oprd.8b00340

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  • M. Tissot, N. Body, S. Petit, J. Claessens, C. Genicot, and P. Pasau, "Synthesis of Electron-Deficient Heteroaromatic 1,3-Substituted Cyclobutyls via Zinc Insertion/Negishi Coupling Sequence under Batch and Automated Flow Conditions", Organic Letters, vol. 20, pp. 8022-8025, 2018. http://dx.doi.org/10.1021/acs.orglett.8b03588
  • Optimization and robustness assessment of a catalytic coupling (here a C-N coupling) using high-throughput experimentation. Performed at Merck Inc.
    Interesting to note how robust the Cu-based catalysts performed compared to Pd-catalysis:

    [1]

  • S. Lin, S. Dikler, W.D. Blincoe, R.D. Ferguson, R.P. Sheridan, Z. Peng, D.V. Conway, K. Zawatzky, H. Wang, T. Cernak, I.W. Davies, D.A. DiRocco, H. Sheng, C.J. Welch, and S.D. Dreher, "Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS", Science, vol. 361, pp. eaar6236, 2018. http://dx.doi.org/10.1126/science.aar6236