asymmetric​_synthesis

Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality

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highlighted in www.chemistryworld.com/news/synthetic-strategy-exploits-fluxional-nitrogen-to-deliver-three-chiral-centres-for-the-price-of-one/4011029.article

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  • C. Dean, S. Rajkumar, S. Roesner, N. Carson, G.J. Clarkson, M. Wills, M. Jones, and M. Shipman, "Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality", Chemical Science, vol. 11, pp. 1636-1642, 2020. http://dx.doi.org/10.1039/C9SC04849A
  • A Method for the Catalytic Enantioselective Synthesis of Chiral a-Azido and a-Amino Ketones from Racemic a-Bromo Ketones, and Its Generalization to the Formation of Bonds to C, O, and S

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  • R. da Silva Gomes, and E.J. Corey, "A Method for the Catalytic Enantioselective Synthesis of Chiral α-Azido and α-Amino Ketones from Racemic α-Bromo Ketones, and Its Generalization to the Formation of Bonds to C, O, and S", Journal of the American Chemical Society, vol. 141, pp. 20058-20061, 2019. http://dx.doi.org/10.1021/jacs.9b12315
  • Enantioselective Synthesis of cis- and trans-Borocyclopropylmethanol: Simple Building Blocks To Access Heterocycle-Substituted Cyclopropylmethanols

    [Charette]


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  • S.H. Siddiqui, C. Navuluri, and A.B. Charette, "Enantioselective Synthesis of cis- and trans-Borocyclopropylmethanol: Simple Building Blocks To Access Heterocycle-Substituted Cyclopropylmethanols", Synthesis, vol. 51, pp. 3834-3846, 2019. http://dx.doi.org/10.1055/s-0037-1611896
  • Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents

    [1]

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  • R. Shinohara, M. Morita, N. Ogawa, and Y. Kobayashi, "Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents", Organic Letters, vol. 21, pp. 3247-3251, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00976
  • Umpolung Reactivity of in Situ Generated Phosphido-Boranes: An Entry to P-Stereogenic Aminophosphine-Boranes

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  • S. Lemouzy, R. Membrat, E. Olivieri, M. Jean, M. Albalat, D. Nuel, L. Giordano, D. Hérault, and G. Buono, "Umpolung Reactivity of in Situ Generated Phosphido-Boranes: An Entry to P-Stereogenic Aminophosphine-Boranes", The Journal of Organic Chemistry, vol. 84, pp. 4551-4557, 2019. http://dx.doi.org/10.1021/acs.joc.9b00333
  • Copper-Catalyzed Asymmetric Conjugate Additions of Bis(pinacolato)diboron and Dimethylzinc to Acyl-N-methylimidazole Michael Acceptors: A Highly Stereoselective Unified Strategy for 1,3,5,…n (OH, Me) Motif Synthesis

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  • J. Lauberteaux, C. Crévisy, O. Baslé, R.M. de Figueiredo, M. Mauduit, and J. Campagne, "Copper-Catalyzed Asymmetric Conjugate Additions of Bis(pinacolato)diboron and Dimethylzinc to Acyl-N-methylimidazole Michael Acceptors: A Highly Stereoselective Unified Strategy for 1,3,5,...n (OH, Me) Motif Synthesis", Organic Letters, vol. 21, pp. 1872-1876, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00479
  • Adventures in Atropisomerism: Development of a Robust, Diastereoselective, Lithium-Catalyzed Atropisomer-Forming Active Pharmaceutical Ingredient Step


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  • S.R. Wisniewski, R. Carrasquillo-Flores, F. Lora Gonzalez, A. Ramirez, M. Casey, M. Soumeillant, T.M. Razler, and B. Mack, "Adventures in Atropisomerism: Development of a Robust, Diastereoselective, Lithium-Catalyzed Atropisomer-Forming Active Pharmaceutical Ingredient Step", Organic Process Research & Development, vol. 22, pp. 1426-1431, 2018. http://dx.doi.org/10.1021/acs.oprd.8b00246