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A robotic platform for flow synthesis of organic compounds informed by AI planning

[new paper by Timothy F. Jamison and Klavs F. Jensen]

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  • C.W. Coley, D.A. Thomas, J.A.M. Lummiss, J.N. Jaworski, C.P. Breen, V. Schultz, T. Hart, J.S. Fishman, L. Rogers, H. Gao, R.W. Hicklin, P.P. Plehiers, J. Byington, J.S. Piotti, W.H. Green, A.J. Hart, T.F. Jamison, and K.F. Jensen, "A robotic platform for flow synthesis of organic compounds informed by AI planning", Science, vol. 365, pp. eaax1566, 2019. http://dx.doi.org/10.1126/science.aax1566
  • ng Carbonyl Coordination of Native Amides for Palladium‐Catalyzed C(sp3)−H Olefination Utilizing Carbonyl Coordination of Native Amides for Palladium‐Catalyzed C(sp3)−H Olefination

    [Jin-Quan Yu]

    [1]

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  • H. Park, Y. Li, and J. Yu, "Utilizing Carbonyl Coordination of Native Amides for Palladium‐Catalyzed C(sp 3 )−H Olefination", Angewandte Chemie International Edition, vol. 58, pp. 11424-11428, 2019. http://dx.doi.org/10.1002/anie.201906075
  • Enantioselective Synthesis of cis- and trans-Borocyclopropylmethanol: Simple Building Blocks To Access Heterocycle-Substituted Cyclopropylmethanols

    [Charette]


    [1]

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  • S.H. Siddiqui, C. Navuluri, and A.B. Charette, "Enantioselective Synthesis of cis- and trans-Borocyclopropylmethanol: Simple Building Blocks To Access Heterocycle-Substituted Cyclopropylmethanols", Synthesis, vol. 51, pp. 3834-3846, 2019. http://dx.doi.org/10.1055/s-0037-1611896
  • Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C–H Bond Arylations


    [1]

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  • A. Benzai, X. Shi, F. Derridj, T. Roisnel, H. Doucet, and J. Soulé, "Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C–H Bond Arylations", The Journal of Organic Chemistry, vol. 84, pp. 13135-13143, 2019. http://dx.doi.org/10.1021/acs.joc.9b01469
  • Ketones from Nickel‐Catalyzed Decarboxylative, Non‐Symmetric Cross‐Electrophile Coupling of Carboxylic Acid Esters

    [Weix]

    [1]

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  • J. Wang, B.P. Cary, P.D. Beyer, S.H. Gellman, and D.J. Weix, "Ketones from Nickel‐Catalyzed Decarboxylative, Non‐Symmetric Cross‐Electrophile Coupling of Carboxylic Acid Esters", Angewandte Chemie International Edition, vol. 58, pp. 12081-12085, 2019. http://dx.doi.org/10.1002/anie.201906000