Optimization and robustness assessment of a catalytic coupling (here a C-N coupling) using high-throughput experimentation. Performed at Merck Inc.
S. Lin, S. Dikler, W.D. Blincoe, R.D. Ferguson, R.P. Sheridan, Z. Peng, D.V. Conway, K. Zawatzky, H. Wang, T. Cernak, I.W. Davies, D.A. DiRocco, H. Sheng, C.J. Welch, and S.D. Dreher, "Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS", Science, vol. 361, pp. eaar6236, 2018. http://dx.doi.org/10.1126/science.aar6236
Interesting to note how robust the Cu-based catalysts performed compared to Pd-catalysis: