juillet 2018 - ChemDigest

26Juil 2018

Iron–Nickel Dual-Catalysis: A New Engine for Olefin Functionalization and the Formation of Quaternary Centers

from the Shenvi lab

[1]

S.A. Green, S. Vásquez-Céspedes, and R.A. Shenvi, "Iron–Nickel Dual-Catalysis: A New Engine for Olefin Functionalization and the Formation of Quaternary Centers", Journal of the American Chemical Society, vol. 140, pp. 11317-11324, 2018. http://dx.doi.org/10.1021/jacs.8b05868

24Juil 2018

The Difluoromethyl Group as a Masked Nucleophile: A Lewis Acid/Base Approach

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[1]

J.B. Geri, M.M. Wade Wolfe, and N.K. Szymczak, "The Difluoromethyl Group as a Masked Nucleophile: A Lewis Acid/Base Approach", Journal of the American Chemical Society, vol. 140, pp. 9404-9408, 2018. http://dx.doi.org/10.1021/jacs.8b06093

24Juil 2018

Using Data Analysis To Evaluate and Compare Chemical Syntheses

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[Hoffmann-La Roche, AsymChem]

Kaiser, Yang, Wuitschik, Org. Process Res. Dev. 2018, 22(9), 1222-1235 [10.1021/acs.oprd.8b00199]

19Juil 2018

Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni’s Reagent

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[1]

Y. Chen, G. Ma, and H. Gong, "Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni’s Reagent", Organic Letters, vol. 20, pp. 4677-4680, 2018. http://dx.doi.org/10.1021/acs.orglett.8b02005

18Juil 2018

Controlling an organic synthesis robot with machine learning to search for new reactivity

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Lee Cronin Lab

[1]

J.M. Granda, L. Donina, V. Dragone, D. Long, and L. Cronin, "Controlling an organic synthesis robot with machine learning to search for new reactivity", Nature, vol. 559, pp. 377-381, 2018. http://dx.doi.org/10.1038/s41586-018-0307-8

10Juil 2018

Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents

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[1]

J. Zhang, J. Yang, H. Zheng, X. Xue, H. Mayr, and J. Cheng, "Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents", Angewandte Chemie International Edition, vol. 57, pp. 12690-12695, 2018. http://dx.doi.org/10.1002/anie.201805859

10Juil 2018

Pd-PEPPSI-IPentAn Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions

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[1]

F. Huang, C. Xu, D. Lu, D. Shen, T. Li, and F. Liu, "Pd-PEPPSI-IPentAn Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions", The Journal of Organic Chemistry, vol. 83, pp. 9144-9155, 2018. http://dx.doi.org/10.1021/acs.joc.8b01205

06Juil 2018

Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides

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[1]

M. Wright, C. Martínez-Lamenca, J.E. Leenaerts, P.E. Brennan, A.A. Trabanco, and D. Oehlrich, "Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides", The Journal of Organic Chemistry, vol. 83, pp. 9510-9516, 2018. http://dx.doi.org/10.1021/acs.joc.8b01244

03Juil 2018

De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors

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An unusual bioisostere phenyl

[1]

Y. Wang, H. Zhao, J.T. Brewer, H. Li, Y. Lao, W. Amberg, B. Behl, I. Akritopoulou-Zanze, J. Dietrich, U.E.W. Lange, F. Pohlki, C. Hoft, W. Hornberger, S.W. Djuric, J. Sydor, M. Mezler, A.L. Relo, and A. Vasudevan, "De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors", Journal of Medicinal Chemistry, vol. 61, pp. 7486-7502, 2018. http://dx.doi.org/10.1021/acs.jmedchem.8b00295

03Juil 2018

Designing Algorithms To Aid Discovery by Chemical Robots

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Lee Cronin Lab

[1]

A.B. Henson, P.S. Gromski, and L. Cronin, "Designing Algorithms To Aid Discovery by Chemical Robots", ACS Central Science, vol. 4, pp. 793-804, 2018. http://dx.doi.org/10.1021/acscentsci.8b00176

Monthly Archives: juillet 2018