Prenylemestrins A and B: Two Unexpected Epipolythiodioxopiperazines with a Thioethanothio Bridge from Emericella sp. Isolated by Genomic Analysis

Par / 8 août 2022 / Non classé

Organic Letters: Latest Articles (ACS Publications)
Authors: Shanshan Chang, Meilian Cai, Tongmei Xiao, Yuchuan Chen, Wuli Zhao, Liyan Yu, Rongguang Shao, Wei Jiang, Tao Zhang, Maoluo Gan, Shuyi Si, and Minghua Chen
dx.doi.org/https://doi.org/10.1021/acs.orglett.2c02187

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AlCl3‑Meditated CHF2 Transfer and Cyclocondensation of Difluoromethoxy Functionalized o‑Phenylenediamines to Access N‑Substituted Benzimidazoles

Par / 8 août 2022 / Non classé

Organic Letters: Latest Articles (ACS Publications)
Authors: Vinothkumar Vinayagam, Satish Kumar Karre, Sreenivasa Reddy Kasu, Ravuri Srinath, Hema Sundar Naveen Babu Bathula, and Subir Kumar Sadhukhan
dx.doi.org/https://doi.org/10.1021/acs.orglett.2c02231

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Discovery of 1‑(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity

Par / 8 août 2022 / medchem

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Yu Zhang, Yingchun Li, Xiang Chen, Xuan Chen, Chao Chen, Li Wang, Xu Dong, Guoli Wang, Ruxin Gu, Fei Li, Feng Han, and Dongyin Chen
dx.doi.org/http://dx.doi.org/10.1021/acs.jmedchem.2c00677

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Development of Dual Practical Manufacturing Routes to Cognate Pyrrolobenzodiazepine-Based Linker-Drugs

Par / 8 août 2022 / Non classé

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Organic Process Research & Development
Organic Process Research & Development: Latest Articles (ACS Publications)

Authors: Stefan G. Koenig, Rémy Angelaud, Christopher M. Crittenden, Kenji Kurita, David J. Russell, Jean-Francois Marcoux, Thomas Matt, and Francis Gosselin
dx.doi.org/https://doi.org/10.1021/acs.oprd.2c00129

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Transition Metal‐Catalyzed Reactions and Solid‐Phase Synthesis: A Convenient Blend

Par / 5 août 2022 / Non classé
Transition Metal-Catalyzed Reactions and Solid-Phase Synthesis: A Convenient Blend

The most recent applications and possibilities of transition metal-catalyzed reactions on solid phase are reviewed, which is a practical and fast strategy to cover current organic chemistry demands. Remarkably, solid-phase CuAAC and ring-closing metathesis have demonstrated an important role in synthetic biology, while more traditional Pd-catalyzed reactions, like Suzuki-Miyaura, Heck, and Sonogashira reactions, are valuable tools for accessing libraries of bioactive compounds.

Abstract

Transition metal-catalyzed, C−C and C−N bond-forming reactions have made an enormous impact in the way complex molecules are assembled. The benefits of solid-phase chemistry soon made this type of reaction applicable to solid-supported processes. In this review, we report the most recent applications and possibilities of this combination. Remarkably, the solid-phase CuAAC and ring-closing metathesis have demonstrated an important role in synthetic biology, alike more traditional Pd-catalyzed reactions, such as Suzuki-Miyaura, Heck, Sonogashira, which are valuable tools for accessing libraries of biologically relevant small molecules. Examples proved the validity of solid-phase transition metal-catalyzed reactions as a practical and fast strategy to cover the current organic chemistry demands.

Wiley: European Journal of Organic Chemistry: Table of Contents
Authors: Patricia G. Cornier, Carina M. L. Delpiccolo, Nadia L. Martiren, Ernesto G. Mata, Luciana Mendez, Caterina Permingeat Squizatto, Marianela G. Pizzio
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202200526

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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1

Par / 5 août 2022 / medchem

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Alexander M. Taylor, Chris Bailey, Lisa D. Belmont, Robert Campbell, Nico Cantone, Alexandre Côté, Terry D. Crawford, Richard Cummings, Kevin DeMent, Martin Duplessis, Megan Flynn, Andrew C. Good, Hon-Ren Huang, Shivangi Joshi, Yves Leblanc, Jeremy Murray, Christopher G. Nasveschuk, Adrianne Neiss, Florence Poy, F. Anthony Romero, Peter Sandy, Yong Tang, Vickie Tsui, Laura Zawadzke, Robert J. Sims, III, James E. Audia, Steven F. Bellon, Steven R. Magnuson, Brian K. Albrecht, and Andrea G. Cochran
dx.doi.org/http://dx.doi.org/10.1021/acs.jmedchem.2c00662

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An Alternative Route to the Anticancer Agent: 2‑Fluorofucose from Readily Available L‑(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction

Par / 5 août 2022 / Non classé

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Organic Process Research & Development
Organic Process Research & Development: Latest Articles (ACS Publications)

Authors: Roozbeh Yousefi, Bradley J. Paul-Gorsline, Omid Soltani, and Kumar D. Ashtekar
dx.doi.org/https://doi.org/10.1021/acs.oprd.2c00146

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Direct Benzylic C(sp3)–O Coupling with Alcohol via Site-Selective C(sp3)–H Cleavage at Room Temperature through a Remote Directing Group-Enabled Radical Relay Strategy

Par / 5 août 2022 / Non classé

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The Journal of Organic Chemistry

The Journal of Organic Chemistry: Latest Articles (ACS Publications)
Authors: Fang Wang, Jiaming Chen, Xiaoqi Jia, Dailin Zhuang, Zhenyang Wan, Lifang Ma, and Ziyuan Li
dx.doi.org/https://doi.org/10.1021/acs.joc.2c00884

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