ChemDigest - Basic bits and bolts of chemistry

29Mar 2019

Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers

R. Martin-Montero, V.R. Yatham, H. Yin, J. Davies, and R. Martin, "Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers", Organic Letters, 2019. http://dx.doi.org/10.1021/acs.orglett.9b01016

28Mar 2019

Efficient Synthesis of α‐Trifluoromethyl Carboxylic Acids and Esters via Fluorocarboxylation of gem‐Difluoroalkenes

by David B ⋅ Leave a Comment

[1]

W. Yoo, J. Kondo, J.A. Rodríguez-Santamaría, T. Nguyen, and S. Kobayashi, "Efficient Synthesis of α-Trifluoromethyl Carboxylic Acids and Esters via Fluorocarboxylation of gem-Difluoroalkenes", Angewandte Chemie International Edition, 2019. http://dx.doi.org/10.1002/anie.201902779

28Mar 2019

Automated Glycan Assembly: A Perspective

by David B ⋅ Leave a Comment

[1]

M. Guberman, and P.H. Seeberger, "Automated Glycan Assembly: A Perspective", Journal of the American Chemical Society, 2019. http://dx.doi.org/10.1021/jacs.9b00638

27Mar 2019

Diastereo‐ and Enantioselective Access to Stereotriads through a Flexible Coupling of Substituted Aldehydes and Alkenes

by David B ⋅ Leave a Comment

[1]

J. Li, A. Preinfalk, and N. Maulide, "Diastereo- and Enantioselective Access to Stereotriads through a Flexible Coupling of Substituted Aldehydes and Alkenes", Angewandte Chemie International Edition, 2019. http://dx.doi.org/10.1002/anie.201900801

27Mar 2019

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

by David B ⋅ Leave a Comment

[1]

T.C. Sherwood, H. Xiao, R.G. Bhaskar, E.M. Simmons, S. Zaretsky, M.P. Rauch, R.R. Knowles, and T.G.M. Dhar, "Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light", The Journal of Organic Chemistry, 2019. http://dx.doi.org/10.1021/acs.joc.9b00432

27Mar 2019

Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides

by David B ⋅ Leave a Comment

[1]

J. Liao, C.H. Basch, M.E. Hoerrner, M.R. Talley, B.P. Boscoe, J.W. Tucker, M.R. Garnsey, and M.P. Watson, "Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides", Organic Letters, 2019. http://dx.doi.org/10.1021/acs.orglett.9b01014

27Mar 2019

Photoredox Catalysis Enables Access to N-Functionalized 2,1-Borazaronaphthalenes

by David B ⋅ Leave a Comment

[1]

X. Wang, G.H.M. Davies, A. Koschitzky, S.R. Wisniewski, C.B. Kelly, and G.A. Molander, "Photoredox Catalysis Enables Access to N-Functionalized 2,1-Borazaronaphthalenes", Organic Letters, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00884

23Mar 2019

Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations

by David B ⋅ Leave a Comment

[1]

G.F. Watt, P. Scott-Stevens, and L. Gaohua, "Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations", Drug Discovery Today: Technologies, 2019. http://dx.doi.org/10.1016/j.ddtec.2019.02.005

22Mar 2019

Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

by David B ⋅ Leave a Comment

[1]

U. Lücking, "Neglected sulfur(vi) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development", Organic Chemistry Frontiers, 2019. http://dx.doi.org/10.1039/C8QO01233D

21Mar 2019

Chromium-Catalyzed Cross-Couplings and Related Reactions

by David B ⋅ Leave a Comment

[1]

J. Li, and P. Knochel, "Chromium-Catalyzed Cross-Couplings and Related Reactions", Synthesis, 2019. http://dx.doi.org/10.1055/s-0037-1611756

21Mar 2019

Protein-slaying drugs could be the next blockbuster therapies

by David B ⋅ Leave a Comment

[1]

M. Scudellari, "Protein-slaying drugs could be the next blockbuster therapies", Nature, vol. 567, pp. 298-300, 2019. http://dx.doi.org/10.1038/d41586-019-00879-3

20Mar 2019

Iterative Assembly of Polycyclic Saturated Heterocycles from Monomeric Building Blocks

by David B ⋅ Leave a Comment

[1]

F. Saito, N. Trapp, and J.W. Bode, "Iterative Assembly of Polycyclic Saturated Heterocycles from Monomeric Building Blocks", Journal of the American Chemical Society, 2019. http://dx.doi.org/10.1021/jacs.9b01537

19Mar 2019

Recent Advances in Minisci‐Type Reactions

by David B ⋅ Leave a Comment

[1]

R.S.J. Proctor, and R.J. Phipps, "Recent Advances in Minisci-Type Reactions", Angewandte Chemie International Edition, 2019. http://dx.doi.org/10.1002/anie.201900977

18Mar 2019

Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides

by David B ⋅ Leave a Comment

[1]

P. Cyr, J. Flynn-Robitaille, P. Boissarie, and A. Marinier, "Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides", Organic Letters, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00557

18Mar 2019

Divergent Synthesis of 1,2-Benzo[e]thiazine and Benzo[d]thiazole Analogues Containing a S-Trifluoromethyl Sulfoximine Group: Preparation and New Properties of the Adachi Reagent

by David B ⋅ Leave a Comment

[1]

A. Barthelemy, E. Anselmi, T. Le, G. Vo-Thanh, R. Guillot, K. Miqueu, and E. Magnier, "Divergent Synthesis of 1,2-Benzo[e]thiazine and Benzo[d]thiazole Analogues Containing a S-Trifluoromethyl Sulfoximine Group: Preparation and New Properties of the Adachi Reagent", The Journal of Organic Chemistry, 2019. http://dx.doi.org/10.1021/acs.joc.9b00079

15Mar 2019

Synthesis and Transformations of Nitrones for Organic Synthesis

by David B ⋅ Leave a Comment

[1]

S. Murahashi, and Y. Imada, "Synthesis and Transformations of Nitrones for Organic Synthesis", Chemical Reviews, 2019. http://dx.doi.org/10.1021/acs.chemrev.8b00476

14Mar 2019

Rapid Deoxyfluorination of Alcohols with 4-Chloro-N- tosylbenzene-1-Sulfonimidoyl Fluoride (SulfoxFluor) at Room Temperature

by David B ⋅ Leave a Comment

[1]

J. Hu, J. Guo, C. Kuang, J. Rong, L. Li, and C. Ni, "Rapid Deoxyfluorination of Alcohols with 4‐Chloro‐N‐tosylbenzene‐1‐Sulfonimidoyl Fluoride (SulfoxFluor) at Room Temperature", Chemistry – A European Journal, 2019. http://dx.doi.org/10.1002/chem.201901176

13Mar 2019

Chematica improves cost assessment and diversity of suggestions

by David B ⋅ Leave a Comment

Further developments of the “computer-aided synthesis planning” software Chematica (bought by Merck and further developed as ‘Synthia’):

[1]

T. Badowski, K. Molga, and B.A. Grzybowski, "Selection of cost-effective yet chemically diverse pathways from the networks of computer-generated retrosynthetic plans", Chemical Science, 2019. http://dx.doi.org/10.1039/C8SC05611K

13Mar 2019

Single-Pot Access to Bisorganoborinates: Applications in Zweifel Olefination

by David B ⋅ Leave a Comment

[1]

A. Music, A.N. Baumann, P. Spieß, N. Hilgert, M. Köllen, and D. Didier, "Single-Pot Access to Bisorganoborinates: Applications in Zweifel Olefination", Organic Letters, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00493

12Mar 2019

Photoredox Radical/Polar Crossover Enables Construction of Saturated Nitrogen Heterocycles

by David B ⋅ Leave a Comment

[1]

L.R.E. Pantaine, J.A. Milligan, J.K. Matsui, C.B. Kelly, and G.A. Molander, "Photoredox Radical/Polar Crossover Enables Construction of Saturated Nitrogen Heterocycles", Organic Letters, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00602

12Mar 2019

Umpolung Reactivity of in Situ Generated Phosphido-Boranes: An Entry to P-Stereogenic Aminophosphine-Boranes

by David B ⋅ Leave a Comment

[1]

S. Lemouzy, R. Membrat, E. Olivieri, M. Jean, M. Albalat, D. Nuel, L. Giordano, D. Hérault, and G. Buono, "Umpolung Reactivity of in Situ Generated Phosphido-Boranes: An Entry to P-Stereogenic Aminophosphine-Boranes", The Journal of Organic Chemistry, 2019. http://dx.doi.org/10.1021/acs.joc.9b00333

11Mar 2019

Direct Alkylation of 1-Azabicyclo[1.1.0]butanes

by David B ⋅ Leave a Comment

[1]

R. Gianatassio, and D. Kadish, "Direct Alkylation of 1-Azabicyclo[1.1.0]butanes", Organic Letters, 2019. http://dx.doi.org/10.1021/acs.orglett.9b00321

08Mar 2019

Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

by David B ⋅ Leave a Comment

[1]

A.R. Bogdan, and A.W. Dombrowski, "Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry", Journal of Medicinal Chemistry, 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01760

07Mar 2019

Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

by David B ⋅ Leave a Comment

[1]

P.Y. Chong, J.B. Shotwell, J. Miller, D.J. Price, A. Maynard, C. Voitenleitner, A. Mathis, S. Williams, J.J. Pouliot, K. Creech, F. Wang, J. Fang, H. Zhang, V.W. Tai, E. Turner, K.M. Kahler, R. Crosby, and A.J. Peat, "Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor", Journal of Medicinal Chemistry, 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01719

07Mar 2019

Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

by David B ⋅ Leave a Comment

[1]

S. Lu, X. He, D. Ni, and J. Zhang, "Allosteric Modulator Discovery: From Serendipity to Structure-Based Design", Journal of Medicinal Chemistry, 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01749

1 2 3 … 14 Suivant »

Post Navigation