Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5′-Nucleotidase Inhibitors

Par / 29 octobre 2020 / medchem

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: Abida Ashraf, Zahid Shafiq, Muhammad Siraj Khan Jadoon, Muhammad Nawaz Tahir, Julie Pelletier, Jean Sevigny, Muhammad Yaqub, and Jamshed Iqbal
feedproxy.google.com/~r/acs/amclct/~3/b9od-P2GdSc/acsmedchemlett.0c00343

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Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma

Par / 29 octobre 2020 / medchem

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Bo Li, Yongliang Li, Céline Tomkiewicz-Raulet, Pascal Dao, Daniel Lietha, Expédite Yen-Pon, Zhiyun Du, Xavier Coumoul, Christiane Garbay, Mélanie Etheve-Quelquejeu, and Huixiong Chen
feedproxy.google.com/~r/acs/jmcmar/~3/zrv2Rqxnw2M/acs.jmedchem.0c01059

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Direct Synthesis of Pyrrolo[1,2-α]quinoxalines via Iron-Catalyzed Transfer Hydrogenation between 1-(2-Nitrophenyl)pyrroles and Alcohols

Par / 29 octobre 2020 / Non classé

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The Journal of Organic Chemistry

The Journal of Organic Chemistry: Latest Articles (ACS Publications)
Authors: Simin Chun, Jiwon Ahn, Ramachandra Reddy Putta, Seok Beom Lee, Dong-Chan Oh, and Suckchang Hong
feedproxy.google.com/~r/acs/joceah/~3/-e5kDlxZ1zI/acs.joc.0c02145

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Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Par / 29 octobre 2020 / medchem

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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
Authors: Michael J. Soth, Kang Le, Maria Emilia Di Francesco, Matthew M. Hamilton, Gang Liu, Jason P. Burke, Chris L. Carroll, Jeffrey J. Kovacs, Jennifer P. Bardenhagen, Christopher A. Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R. Garvey, Jason P. Gay, Mary K. Geck Do, Jennifer Greer, Michelle Han, Angela Harris, Zachary Herrera, Sha Huang, Virginia Giuliani, Yongying Jiang, Sarah B. Johnson, Troy A. Johnson, Zhijun Kang, Paul G. Leonard, Zhen Liu, Timothy McAfoos, Meredith Miller, Pietro Morlacchi, Robert A. Mullinax, Wylie S. Palmer, Jihai Pang, Norma Rogers, Charles M. Rudin, Hannah E. Shepard, Nakia D. Spencer, Jay Theroff, Qi Wu, Alan Xu, Ju Anne Yau, Giulio Draetta, Carlo Toniatti, Timothy P. Heffernan, and Philip Jones
feedproxy.google.com/~r/acs/jmcmar/~3/tx0UPHOUdnI/acs.jmedchem.0c01398

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DBU-Promoted Cascade Selective Nucleophilic Addition/C–C Bond Cleavage/Hetero-Diels–Alder Reactions of 2-Amino-4H-chromen-4-ones with β-Nitrostyrenes and/or Aryl Aldehydes: Access to 5H-Chromeno[2,3-b]pyridin-5-ones

Par / 29 octobre 2020 / Non classé

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The Journal of Organic Chemistry

The Journal of Organic Chemistry: Latest Articles (ACS Publications)
Authors: Naili Luo, Shan Wang, Yue Zhang, Junhu Xin, and Cunde Wang
feedproxy.google.com/~r/acs/joceah/~3/M-dHUkkaDNc/acs.joc.0c01993

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Developing a Multistep Continuous Manufacturing Process for (1R,2R)-2-Amino-1-methylcyclopentan-1-ol

Par / 28 octobre 2020 / Non classé

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Organic Process Research & Development

Organic Process Research & Development: Latest Articles (ACS Publications)

Authors: Shengquan Duan, Xichun Feng, Miguel Gonzalez, Scott Bader, Cheryl Hayward, Tomislav Ljubicic, Jiangping Lu, Jason Mustakis, Mark Maloney, Joseph Rainville, and Xin Zhang
feedproxy.google.com/~r/acs/oprdfk/~3/HGG_7cAx-jE/acs.oprd.0c00405

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Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

Par / 28 octobre 2020 / medchem

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ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Latest Articles (ACS Publications)
Authors: James S. Scott, Thomas A. Moss, Bernard Barlaam, Paul R. J. Davey, Gary Fairley, Eric T. Gangl, Ryan D. R. Greenwood, Holia Hatoum-Mokdad, Andrew S. Lister, David Longmire, Radoslaw Polanski, Stephen Stokes, Michael J. Tucker, Jeffrey G. Varnes, and Bin Yang
feedproxy.google.com/~r/acs/amclct/~3/UoxnN4llQJw/acsmedchemlett.0c00505

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Green Chemistry Articles of Interest to the Pharmaceutical Industry

Par / 28 octobre 2020 / Non classé
Organic Process Research & Development

Organic Process Research & Development: Latest Articles (ACS Publications)

Authors: Alba Diaz Rodriguez, Charlotte Dalton, Louis Diorazio, Jaika Doerfler, Oliver D. Engl, Matthew Hickey, Gareth Howell, Marc Hutchby, Jonathan Latham, Wei Li, Rachel Munday, Paul Richardson, Philipp C. Roosen, Alan Steven, Jack A. Terrett, Daniel S. Treitler, Timothy White, and Mingshuo Zeng
feedproxy.google.com/~r/acs/oprdfk/~3/VArf9PV1aSk/acs.oprd.0c00456

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Photoinduced Syntheses and Reactivities of Phosphorus-Containing Interelement Compounds

Par / 28 octobre 2020 / Non classé

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The Journal of Organic Chemistry

The Journal of Organic Chemistry: Latest Articles (ACS Publications)
Authors: Yuki Yamamoto, Ryo Tanaka, Miyuto Ota, Misaki Nishimura, Cong Chi Tran, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, and Akiya Ogawa
feedproxy.google.com/~r/acs/joceah/~3/bXsPMoOLGr4/acs.joc.0c02014

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Correction to “Metal-Free Synthesis of 4-Chloroisocoumarins by TMSCl-Catalyzed NCS-Induced Chlorinative Annulation of 2-Alkynylaryloate Esters”

Par / 28 octobre 2020 / Non classé

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The Journal of Organic Chemistry

The Journal of Organic Chemistry: Latest Articles (ACS Publications)
Authors: Krissada Norseeda, Nattawadee Chaisan, Charnsak Thongsornkleeb, Jumreang Tummatorn, and Somsak Ruchirawat
feedproxy.google.com/~r/acs/joceah/~3/I46IVsOw7Rc/acs.joc.0c02380

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Synthesis of a 3,4-Dihydro-1,3-oxazin-2-ones Skeleton via an Intermolecular [4 + 2] Process of N-Acyliminium Ions with Ynamides/Terminal Alkynes

Par / 28 octobre 2020 / Non classé

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The Journal of Organic Chemistry

The Journal of Organic Chemistry: Latest Articles (ACS Publications)
Authors: Xiao-Li Han, Xiao-Di Nie, Zhao-Dan Chen, Chang-Mei Si, Bang-Guo Wei, and Guo-Qiang Lin
feedproxy.google.com/~r/acs/joceah/~3/VGEdqfw-bQI/acs.joc.0c01692

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